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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,851–13,900 of 31,435, by identifier

L-tryptophan + 2-oxoglutarate = indole-3-pyruvate + L-glutamate
Direction not assertedBalancedRhea 14093
3-phenylpyruvate + L-aspartate = oxaloacetate + L-phenylalanine
Direction not assertedBalancedRhea 14097
[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O
Direction not assertedBalance undeterminableRhea 14101
L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)
Right to leftBalancedRhea 14105
L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)
Right to leftBalancedRhea 14109
a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate
Direction not assertedBalance undeterminableRhea 14113
[(1->4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-1)

Direction not assertedBalance undeterminableRhea 14117

3,4-dihydroxy-5-(all-trans-hexaprenyl)benzoate + S-adenosyl-L-methionine = 4-hydroxy-3-methoxy-5-(all-trans-hexaprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 14121

2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose

Direction not assertedBalancedRhea 14125

cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H(+)

Direction not assertedBalancedRhea 14129

(-)-tabersonine + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxytabersonine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 14133

beta-D-galactosyl-(1<->1)-sphing-4-enine + 3'-phosphoadenylyl sulfate = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 14137

glutathione disulfide + sulfite + AMP + 2 H(+) = adenosine 5'-phosphosulfate + 2 glutathione

Direction not assertedBalancedRhea 14141

guanidinoacetate + ATP = phosphoguanidinoacetate + ADP + H(+)

Direction not assertedBalancedRhea 14145

luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP + H(+)

Direction not assertedBalancedRhea 14149

17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + UDP + H(+)

Direction not assertedBalancedRhea 14153

triphosphate + H2O = phosphate + diphosphate

Left to rightBalancedRhea 14157

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

Direction not assertedBalancedRhea 14161

L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)

Left to rightBalancedRhea 14165

glutarate + ATP + CoA = glutaryl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 14169

dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate

Direction not assertedBalancedRhea 14173

(R)-amygdalin + H2O = (R)-prunasin + D-glucose

Direction not assertedBalancedRhea 14177

N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2

Direction not assertedBalancedRhea 14181

3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2

Direction not assertedBalancedRhea 14185

D-tryptophan + O2 = N-formyl-D-kynurenine

Direction not assertedBalancedRhea 14189

3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O

Direction not assertedBalancedRhea 14193

L-aspartate + NH4(+) + ATP = L-asparagine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 14197

D-lyxose = D-xylulose

Direction not assertedBalancedRhea 14201

carnosine + S-adenosyl-L-methionine = anserine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 14205

alpha-D-galactose 1-phosphate + UTP + H(+) = UDP-alpha-D-galactose + diphosphate

Direction not assertedBalancedRhea 14209

beta-D-fructose 1-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 14213

L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 14217

monomethyl sulfate + H2O = methanol + sulfate + H(+)

Direction not assertedBalancedRhea 14221

6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + NADH + H(+)

Direction not assertedBalancedRhea 14225

(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 14229

a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

Direction not assertedBalance undeterminableRhea 14233

10-deoxysarpagine + reduced [NADPH--hemoprotein reductase] + O2 = sarpagine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 14237

3-amino-4-hydroxybenzaldehyde + acetyl-CoA = 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)

Direction not assertedBalancedRhea 14241

ATP + H2O = AMP + diphosphate + H(+)

Left to rightBalancedRhea 14245

guanosine 3',5'-bis(diphosphate) + H2O = GDP + diphosphate + H(+)

Direction not assertedBalancedRhea 14253

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)

Left to rightBalance undeterminableRhea 14257

(E)-sinapoyl-CoA + D-glucono-1,5-lactone = 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA

Direction not assertedBalancedRhea 14261

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate

Direction not assertedBalancedRhea 14265

2 a quinone + NADPH + H(+) = 2 a 1,4-benzosemiquinone + NADP(+)

Left to rightBalance undeterminableRhea 14269

spermidine + A + H2O = 4-aminobutanal + propane-1,3-diamine + AH2

Direction not assertedBalancedRhea 14273

(S)-lactaldehyde + NAD(+) + H2O = (S)-lactate + NADH + 2 H(+)

Direction not assertedBalancedRhea 14277

2 Fe(III)-[cytochrome c] + sulfite + H2O = 2 Fe(II)-[cytochrome c] + sulfate + 2 H(+)

Direction not assertedBalance undeterminableRhea 14281

sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 14285

a dicarboxylate + ATP + CoA = omega-dicarboxyl-CoA + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 14289

D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)

Left to rightBalancedRhea 14293

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