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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,801–13,850 of 31,435, by identifier

FAD + H2O = FMN + AMP + 2 H(+)
Left to rightBalancedRhea 13889
P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)
Left to rightBalancedRhea 13893
chorismate = prephenate
Direction not assertedBalancedRhea 13897
N-(aminomethyl)urea + H2O = N-(hydroxymethyl)urea + NH4(+)
Direction not assertedBalancedRhea 13901
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
Left to rightBalance undeterminableRhea 13905
urate D-ribonucleoside + phosphate = alpha-D-ribose 1-phosphate + urate
Direction not assertedBalancedRhea 13909
L-threonine = D-threonine

? Direction not asserted

Balanced

Rhea 13913

(-)-menthol + NADP(+) = (1R,4S)-menthone + NADPH + H(+)

Direction not assertedBalancedRhea 13917

ent-kaur-16-en-19-oate + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = gibberellin A12 aldehyde + 4 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O

Direction not assertedBalance undeterminableRhea 13921

(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]

Direction not assertedBalance undeterminableRhea 13925

agmatine + H2O = urea + putrescine

Direction not assertedBalancedRhea 13929

all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)

Left to rightBalancedRhea 13933

4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + sulfite + NAD(+)

Direction not assertedBalancedRhea 13937

D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 13941

(S)-mandelate = (R)-mandelate

Direction not assertedBalancedRhea 13945

2 reduced [rubredoxin] + NADP(+) + H(+) = 2 oxidized [rubredoxin] + NADPH

Direction not assertedBalance undeterminableRhea 13949

a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)

Direction not assertedBalance undeterminableRhea 13953

4 sulfur + O2 + 4 H2O = 2 hydrogen sulfide + 2 sulfite + 6 H(+)

Direction not assertedBalancedRhea 13957

protoporphyrin IX + Mg(2+) + ATP + H2O = Mg-protoporphyrin IX + ADP + phosphate + 3 H(+)

Direction not assertedBalancedRhea 13961

L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)

Direction not assertedBalancedRhea 13965

a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + GMP + diphosphate

Direction not assertedBalance undeterminableRhea 13969

diphosphate + H2O + H(+)(in) = 2 phosphate + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 13973

D-serine = pyruvate + NH4(+)

Direction not assertedBalancedRhea 13977

L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)

Direction not assertedBalancedRhea 13985

alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Direction not assertedBalancedRhea 13989

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

Left to rightBalancedRhea 13993

3-methyl-2-oxobutanoate + NAD(+) + CoA = 2-methylpropanoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 13997

choloyl-CoA + glycine = glycocholate + CoA + H(+)

Left to rightBalancedRhea 14001

L,L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4(+)

Left to rightBalancedRhea 14005

2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate

Direction not assertedBalancedRhea 14009

taurolithocholate + 3'-phosphoadenylyl sulfate = taurolithocholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 14013

beta-nicotinamide D-riboside + ATP = beta-nicotinamide D-ribonucleotide + ADP + H(+)

Direction not assertedBalancedRhea 14017

ecdysone + AH2 + O2 = 20-hydroxyecdysone + A + H2O

Direction not assertedBalancedRhea 14021

L-sepiapterin + H2O + H(+) = (S)-xanthopterin-B2 + NH4(+)

Direction not assertedBalancedRhea 14025

selenite + A + H2O = selenate + AH2

Direction not assertedBalancedRhea 14029

sn-glycero-3-phospho-1D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + glycerol + H(+)

Left to rightBalancedRhea 14033

4,5beta-dihydrocortisone + NADP(+) = cortisone + NADPH + H(+)

Right to leftBalancedRhea 14037

(R)-vicianin + H2O = vicianose + mandelonitrile

Direction not assertedBalancedRhea 14041

1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2

Direction not assertedBalancedRhea 14045

taxa-4(5),11(12)-diene + reduced [NADPH--hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 14049

D-arabinose 5-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate

Direction not assertedBalancedRhea 14053

a glycerophospholipid + a 1,2-diacyl-sn-glycerol = a monoacylglycerophospholipid + a triacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 14057

N-(carboxymethyl)-D-alanine + NAD(+) + H2O = glycine + pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 14061

scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O

Direction not assertedBalancedRhea 14065

D-fructose + NADP(+) = 5-dehydro-D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 14069

3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2

Direction not assertedBalancedRhea 14073

3-oxopropanoate + L-alanine = beta-alanine + pyruvate

Right to leftBalancedRhea 14077

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 14081

5-methylaminomethyl-2-thiouridine(34) in tRNA + (2E)-geranyl diphosphate = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate

Direction not assertedBalancedRhea 14085

glycine + 2-oxoglutarate = glyoxylate + L-glutamate

Direction not assertedBalancedRhea 14089

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