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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,701–13,750 of 31,435, by identifier

(S)-2,3-diaminopropanoate + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA
Direction not assertedBalancedRhea 13465
thymine + A + H2O = 5-methylbarbiturate + AH2 + H(+)
Direction not assertedBalancedRhea 13469
L-tryptophan + NAD(+) + H2O = indole-3-pyruvate + NH4(+) + NADH + H(+)
Direction not assertedBalancedRhea 13473
L-tryptophan + NADP(+) + H2O = indole-3-pyruvate + NH4(+) + NADPH + H(+)
Direction not assertedBalancedRhea 13477
tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate
Direction not assertedBalancedRhea 13481
S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate
Direction not assertedBalancedRhea 13485
(S)-canadine + 2 O2 + H(+) = berberine + 2 H2O2

Direction not assertedBalancedRhea 13489

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)

Direction not assertedBalancedRhea 13493

5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)

Direction not assertedBalancedRhea 13497

N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 13501

choline + O2 = betaine aldehyde + H2O2

Direction not assertedBalancedRhea 13505

N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate

Left to rightBalancedRhea 13509

(S)-dihydroorotate + NAD(+) = orotate + NADH + H(+)

Direction not assertedBalancedRhea 13513

dTMP + ATP = dTDP + ADP

Direction not assertedBalancedRhea 13517

(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)

Direction not assertedBalance undeterminableRhea 13521

2 reduced [2Fe-2S]-[putidaredoxin] + (1R,4R)-camphor + O2 + 2 H(+) = (1R,4R,5R)-5-hydroxycamphor + 2 oxidized [2Fe-2S]-[putidaredoxin] + H2O

Direction not assertedBalance undeterminableRhea 13525

(3S)-citramalate = mesaconate + H2O

Direction not assertedBalancedRhea 13529

(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)

Direction not assertedBalancedRhea 13537

tetrathionate + H2O = sulfur + thiosulfate + sulfate + H(+)

Direction not assertedBalancedRhea 13541

(6E,10E)-geranyllinalool + reduced [NADPH--hemoprotein reductase] + O2 = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 13545

beta-L-fucose 1-phosphate + GTP + H(+) = GDP-beta-L-fucose + diphosphate

Left to rightBalancedRhea 13549

alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)

Left to rightBalancedRhea 13553

gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

Left to rightBalancedRhea 13557

meso-2,6-diaminopimelate + NADP(+) + H2O = (S)-2-amino-6-oxoheptanedioate + NH4(+) + NADPH + H(+)

Direction not assertedBalancedRhea 13561

4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)

Direction not assertedBalance undeterminableRhea 13565

[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate = [(1->4)-alpha-D-galacturonosyl](n+1) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 13573

a long-chain alcohol wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 13577

N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP + H(+)

Direction not assertedBalance undeterminableRhea 13581

butanoate + ATP = butanoyl phosphate + ADP

Direction not assertedBalancedRhea 13585

3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 13589

1,4-diguanidinobutane + H2O = agmatine + urea

Direction not assertedBalancedRhea 13597

cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + NADH + H(+)

Right to leftBalancedRhea 13601

2 L-ascorbate + O2 = 2 L-dehydroascorbate + 2 H2O

Direction not assertedBalancedRhea 13605

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 13609

beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + phosphate + H(+)

Direction not assertedBalancedRhea 13613

S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine

Direction not assertedBalancedRhea 13617

4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose

Direction not assertedBalance undeterminableRhea 13621

N(6)-dimethylallyladenine + A + H2O = 3-methyl-2-butenal + adenine + AH2

Direction not assertedBalancedRhea 13625

(1S,5R)-carveol + NADP(+) = (R)-carvone + NADPH + H(+)

Direction not assertedBalancedRhea 13629

putrescine + L-glutamate + ATP = gamma-L-glutamylputrescine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 13633

methane + NADH + O2 + H(+) = methanol + NAD(+) + H2O

Direction not assertedBalancedRhea 13637

methane + NADPH + O2 + H(+) = methanol + NADP(+) + H2O

Direction not assertedBalancedRhea 13641

[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose

Direction not assertedBalance undeterminableRhea 13653

acetyl-[citrate lyase ACP] + H2O = holo-[citrate lyase ACP] + acetate + H(+)

Direction not assertedBalance undeterminableRhea 13657

N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH4(+)

Direction not assertedBalancedRhea 13661

GTP = 3',5'-cyclic GMP + diphosphate

Left to rightBalancedRhea 13665

5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2

Direction not assertedBalancedRhea 13669

[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate

Direction not assertedBalance undeterminableRhea 13673

D-ribulose 5-phosphate = D-xylulose 5-phosphate

Direction not assertedBalancedRhea 13677

a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 13681

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