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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,501–13,550 of 31,435, by identifier

N-acetyl-alpha-D-galactosamine + ATP = N-acetyl-alpha-D-galactosamine 1-phosphate + ADP + H(+)
Direction not assertedBalancedRhea 12617
L-aspartate + H(+) = L-alanine + CO2
Direction not assertedBalancedRhea 12621
1-O-(trans-sinapoyl)-beta-D-glucose + (S)-malate = sinapoyl (S)-malate + D-glucose
Direction not assertedBalancedRhea 12625
L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-6-hydroxyhyoscyamine + succinate + CO2
Direction not assertedBalancedRhea 12629
benzoate + NADH + O2 + H(+) = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)
Direction not assertedBalancedRhea 12633
(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP + H(+)
Direction not assertedBalance undeterminableRhea 12637

(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)

Direction not assertedBalancedRhea 12641

indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] + CoA = (indol-3-yl)acetyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 12645

L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + NADH + H(+)

Direction not assertedBalancedRhea 12649

(S)-malate + NAD(+) = pyruvate + CO2 + NADH

Direction not assertedBalancedRhea 12653

a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA

ReversibleBalance undeterminableRhea 12657

(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

ReversibleBalancedRhea 12661

a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3)-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)

Direction not assertedBalance undeterminableRhea 12665

O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate

Left to rightBalance undeterminableRhea 12669

an aliphatic primary amide = an aliphatic nitrile + H2O

Direction not assertedBalance undeterminableRhea 12673

Latia luciferin + AH2 + 2 O2 = oxidized Latia luciferin + hnu + formate + A + CO2 + H2O + H(+)

Direction not assertedBalance undeterminableRhea 12677

creatinine + H2O + H(+) = N-methylhydantoin + NH4(+)

Direction not assertedBalancedRhea 12681

2 mycothiol + NADP(+) = mycothione + NADPH + H(+)

Direction not assertedBalancedRhea 12685

2 mycothiol + NAD(+) = mycothione + NADH + H(+)

Direction not assertedBalancedRhea 12689

3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)

Direction not assertedBalancedRhea 12693

dGMP + ATP = dGDP + ADP

Direction not assertedBalancedRhea 12697

a 2'-deoxyribonucleoside 5'-triphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-triphosphate + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 12701

[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine

Left to rightBalance undeterminableRhea 12705

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 12709

a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)

Direction not assertedBalance undeterminableRhea 12713

1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 12717

S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

Direction not assertedBalancedRhea 12721

D-iditol + NAD(+) = keto-D-sorbose + NADH + H(+)

Direction not assertedBalancedRhea 12725

lutein = (3R,3'S)-zeaxanthin

Direction not assertedBalancedRhea 12729

nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

Direction not assertedBalancedRhea 12733

[PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine + 5-aminopentanoate = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline

Direction not assertedBalance undeterminableRhea 12737

ADP + H2O + H(+) = IDP + NH4(+)

Direction not assertedBalancedRhea 12741

a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)

Direction not assertedBalance undeterminableRhea 12745

3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2

Direction not assertedBalancedRhea 12749

glycerol + NADP(+) = dihydroxyacetone + NADPH + H(+)

Direction not assertedBalancedRhea 12753

dihydrozeatin + NADP(+) = zeatin + NADPH + H(+)

Direction not assertedBalancedRhea 12757

precorrin-3B + S-adenosyl-L-methionine = precorrin-4 + S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalancedRhea 12761

2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate + CoA = 2 reduced [2Fe-2S]-[ferredoxin] + acetyl-CoA + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 12765

D-gluconate + A = 2-dehydro-D-gluconate + AH2

Direction not assertedBalancedRhea 12769

proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O

Direction not assertedBalancedRhea 12773

2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity

Direction not assertedBalance undeterminableRhea 12777

an alditol + NAD(+) = an aldose + NADH + H(+)

Direction not assertedBalance undeterminableRhea 12785

an alditol + NADP(+) = an aldose + NADPH + H(+)

Right to leftBalance undeterminableRhea 12789

1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP

Direction not assertedBalancedRhea 12793

(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2 + H2O + H(+)

Direction not assertedBalancedRhea 12797

L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)

Left to rightBalance undeterminableRhea 12801

(S)-canadine + S-adenosyl-L-methionine = (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 12805

4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O

Direction not assertedBalancedRhea 12809

L-glutamate = D-glutamate

ReversibleBalancedRhea 12813

2,3-dihydrobiochanin A + NADP(+) = biochanin A + NADPH + 2 H(+)

Direction not assertedBalancedRhea 12817

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