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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,401–13,450 of 31,435, by identifier

keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O
Direction not assertedBalancedRhea 12196
2'-deoxymugineate + 2-oxoglutarate + O2 = mugineate + succinate + CO2
Direction not assertedBalancedRhea 12200
dihydromonacolin L carboxylate + reduced [NADPH--hemoprotein reductase] + O2 = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 12204
4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
Direction not assertedBalancedRhea 12208
9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + NADPH + H(+)
Direction not assertedBalancedRhea 12212
9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + NADH + H(+)
Direction not assertedBalancedRhea 12216

L-leucine + NAD(+) + H2O = 4-methyl-2-oxopentanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 12220

L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 12228

acetyl phosphate + [thioredoxin]-disulfide + NH4(+) + H2O = [thioredoxin]-dithiol + glycine + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 12232

nicotinate + NADP(+) + H2O = 6-hydroxynicotinate + NADPH + H(+)

Direction not assertedBalancedRhea 12236

3 malonyl-CoA + acetyl-CoA + NADPH + 3 H(+) = 6-methylsalicylate + 3 CO2 + NADP(+) + 4 CoA + H2O

Direction not assertedBalancedRhea 12240

UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H(+)

Direction not assertedBalancedRhea 12248

4-O-(beta-D-glucosyl)-(E)-coniferol + H2O = (E)-coniferol + D-glucose

Direction not assertedBalancedRhea 12252

L-arogenate + NAD(+) = L-tyrosine + CO2 + NADH

Direction not assertedBalancedRhea 12256

NADH + ATP = ADP + NADPH + H(+)

Direction not assertedBalancedRhea 12260

putrescine + 2-oxoglutarate = 1-pyrroline + L-glutamate + H2O

Direction not assertedBalancedRhea 12268

L-dopa + H(+) = dopamine + CO2

Direction not assertedBalancedRhea 12272

3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 12276

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 12280

3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate

ReversibleBalancedRhea 12284

an alpha-L-fucoside + H2O = L-fucose + an alcohol

Left to rightBalance undeterminableRhea 12288

tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 12292

deacetylipecoside + H2O = secologanin + dopamine

Direction not assertedBalancedRhea 12296

uridine(47) in tRNA(Phe) + S-adenosyl-L-methionine = 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalance undeterminableRhea 12300

(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 12304

(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)

Left to rightBalancedRhea 12308

dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + NAD(+) + H2O + H(+)

Direction not assertedBalancedRhea 12312

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

Left to rightBalance undeterminableRhea 12316

17-O-acetylnorajmaline + NADP(+) = (2R)-1,2-dihydrovomilenine + NADPH + 2 H(+)

Direction not assertedBalancedRhea 12320

N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-D-glucosamine + L-asparagine

Direction not assertedBalancedRhea 12324

[(1->3)-alpha-D-glucosyl](n) + phosphate = [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate

Direction not assertedBalance undeterminableRhea 12328

Fe(3+)(out) + ATP + H2O = Fe(3+)(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 12332

carboxymethoxysuccinate = glycolate + fumarate

Direction not assertedBalancedRhea 12336

N-terminal L-lysyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 12340

(S)-4-amino-5-oxopentanoate + tRNA(Glu) + NADP(+) = L-glutamyl-tRNA(Glu) + NADPH + H(+)

Direction not assertedBalancedRhea 12344

(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate

Direction not assertedBalancedRhea 12348

L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2

Direction not assertedBalancedRhea 12352

D-mannose 6-phosphate = D-fructose 6-phosphate

Direction not assertedBalancedRhea 12356

13-hydroxylupanine + (2E)-2-methylbut-2-enoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA

Direction not assertedBalancedRhea 12360

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

Direction not assertedBalance undeterminableRhea 12364

2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2

Direction not assertedBalancedRhea 12368

2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)

Direction not assertedBalancedRhea 12372

L-fuculose + ATP = L-fuculose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 12376

L-2,4-diaminobutanoate + pyruvate = L-aspartate 4-semialdehyde + L-alanine

Direction not assertedBalancedRhea 12380

5,6-dihydrouracil + O2 = uracil + H2O2

Direction not assertedBalancedRhea 12384

formononetin + reduced [NADPH--hemoprotein reductase] + O2 = 2'-hydroxyformononetin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 12388

dTDP-D-galactose + 2 NADP(+) + H2O = dTDP-D-galacturonate + 2 NADPH + 3 H(+)

Direction not assertedBalancedRhea 12396

beta-nicotinamide D-ribonucleotide + H2O = nicotinate beta-D-ribonucleotide + NH4(+)

Direction not assertedBalancedRhea 12400

D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)

Left to rightBalancedRhea 12404

L-lysine + NAD(+) = L-1-piperideine-6-carboxylate + NH4(+) + NADH + 2 H(+)

Direction not assertedBalancedRhea 12408

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