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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,351–13,400 of 31,435, by identifier

progesterone + AH2 + O2 = testosterone acetate + A + H2O
Direction not assertedBalancedRhea 11984
a 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = a 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalance undeterminableRhea 11988
L-pipecolate + O2 = L-1-piperideine-6-carboxylate + H2O2 + H(+)
Direction not assertedBalancedRhea 11992
biphenyl-2-ol + NADH + O2 + H(+) = biphenyl-2,3-diol + NAD(+) + H2O
Direction not assertedBalancedRhea 11996
formate + NADP(+) = CO2 + NADPH
Direction not assertedBalancedRhea 12000
indoxyl + UDP-alpha-D-glucose = indican + UDP + H(+)
Direction not assertedBalancedRhea 12004
[G protein-coupled receptor] + ATP = [G protein-coupled receptor]-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 12008

thiamine + ATP = thiamine phosphate + ADP + H(+)

Direction not assertedBalancedRhea 12012

(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate

Direction not assertedBalancedRhea 12016

a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)

Direction not assertedBalance undeterminableRhea 12020

1-O-(trans-sinapoyl)-beta-D-glucose + choline = O-sinapoylcholine + D-glucose

Direction not assertedBalancedRhea 12024

L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate + H(+)

Direction not assertedBalancedRhea 12028

a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 12032

(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 12036

(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 12040

a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 12044

3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate

Direction not assertedBalancedRhea 12048

(2E,6E)-farnesyl diphosphate = trichodiene + diphosphate

Direction not assertedBalancedRhea 12052

D-erythrose 4-phosphate + NAD(+) + H2O = 4-phospho-D-erythronate + NADH + 2 H(+)

Direction not assertedBalancedRhea 12056

6 malonyl-CoA + acetyl-CoA + 5 H(+) = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O

Direction not assertedBalancedRhea 12060

apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 12068

an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)

Direction not assertedBalance undeterminableRhea 12072

an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + NADH + H(+)

Direction not assertedBalance undeterminableRhea 12076

malonyl-[ACP] + acetyl-CoA + H(+) = 3-oxobutanoyl-[ACP] + CO2 + CoA

Direction not assertedBalance undeterminableRhea 12080

D-mannitol + NAD(+) = D-fructose + NADH + H(+)

Direction not assertedBalancedRhea 12084

an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

Left to rightBalance undeterminableRhea 12088

(S)-acetoin = (R)-acetoin

Direction not assertedBalancedRhea 12092

N-benzylformamide + H2O = benzylamine + formate

Direction not assertedBalancedRhea 12096

1,5-anhydro-D-fructose = microthecin + H2O

Direction not assertedBalancedRhea 12100

dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP

Left to rightBalancedRhea 12104

indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 12112

Direction not assertedBalancedRhea 12116

alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate

Direction not assertedBalancedRhea 12120

shikimate + 4-coumaroyl-CoA = trans-4-coumaroylshikimate + CoA

Direction not assertedBalancedRhea 12124

2 oxidized [2Fe-2S]-[ferredoxin] + 2 L-glutamate = L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] + 2-oxoglutarate + 2 H(+)

Direction not assertedBalance undeterminableRhea 12128

Cd(2+)(in) + ATP + H2O = Cd(2+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 12132

a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 12136

a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)

Direction not assertedBalance undeterminableRhea 12140

cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 12144

(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)

Direction not assertedBalancedRhea 12152

2-glutathionyl-2-methylbut-3-en-1-ol + 2 NAD(+) + H2O = 2-glutathionyl-2-methylbut-3-enoate + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 12156

2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + NADH + H(+)

Direction not assertedBalancedRhea 12160

a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 12164

allyl alcohol + NADP(+) = acrolein + NADPH + H(+)

Direction not assertedBalancedRhea 12168

alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

ReversibleBalancedRhea 12172

phenylethanolamine + S-adenosyl-L-methionine = N-methylphenylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 12176

anthranilate + S-adenosyl-L-methionine = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 12180

(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + NADH + H(+)

Direction not assertedBalancedRhea 12184

N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2

Left to rightBalance undeterminableRhea 12188

(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate

Direction not assertedBalancedRhea 12192

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