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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,301–13,350 of 31,435, by identifier

L-aspartate + NADP(+) + H2O = oxaloacetate + NH4(+) + NADPH + H(+)
Direction not assertedBalancedRhea 11784
L-aspartate + NAD(+) + H2O = oxaloacetate + NH4(+) + NADH + H(+)
Direction not assertedBalancedRhea 11788
propene + NADH + O2 + H(+) = 1,2-epoxypropane + NAD(+) + H2O
Direction not assertedBalancedRhea 11792
ecdysone + O2 = 3-dehydroecdysone + H2O2
Direction not assertedBalancedRhea 11796
NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)
Left to rightBalancedRhea 11800
an aromatic aldehyde + NAD(+) + H2O = an aromatic carboxylate + NADH + 2 H(+)
Direction not assertedBalance undeterminableRhea 11804
bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 11808

methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

Direction not assertedBalancedRhea 11812

alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate

ReversibleBalancedRhea 11816

diphthamide-[translation elongation factor 2] + NAD(+) = N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 11820

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate

Direction not assertedBalancedRhea 11824

a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)

Left to rightBalance undeterminableRhea 11828

(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = naphthalene-1,2-diol + NADH + H(+)

Direction not assertedBalancedRhea 11832

N-acetyllactosamine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine + CMP + H(+)

Direction not assertedBalancedRhea 11836

benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+)

Left to rightBalancedRhea 11840

formate + acetyl-CoA = pyruvate + CoA

Direction not assertedBalancedRhea 11844

acetyl phosphate + trimethylamine + [thioredoxin]-disulfide + H2O = glycine betaine + [thioredoxin]-dithiol + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 11848

S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine

Left to rightBalancedRhea 11852

1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 11856

L-histidyl-[protein] + ATP = N(tele)-phospho-L-histidyl-[protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 11860

trimethylamine + oxidized [electron-transfer flavoprotein] + H2O + H(+) = dimethylamine + reduced [electron-transfer flavoprotein] + formaldehyde

Direction not assertedBalance undeterminableRhea 11864

D-arabinitol + NADP(+) = D-ribulose + NADPH + H(+)

Direction not assertedBalancedRhea 11868

corticosterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 11872

prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

Left to rightBalancedRhea 11876

(S)-6-hydroxynicotine + O2 + H2O = 6-hydroxypseudooxynicotine + H2O2

Direction not assertedBalancedRhea 11880

cortisol + 3'-phosphoadenylyl sulfate = cortisol 21-sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 11884

an aldehyde + NADP(+) + H2O = a carboxylate + NADPH + 2 H(+)

Left to rightBalance undeterminableRhea 11888

6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = nororientaline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 11892

7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + NADH + H(+)

Left to rightBalancedRhea 11896

(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH

Direction not assertedBalancedRhea 11900

2-amino-4-hydroxypteridine + H2O + H(+) = 2,4-dihydroxypteridine + NH4(+)

Direction not assertedBalancedRhea 11904

nonane-4,6-dione + H2O = pentan-2-one + butanoate + H(+)

Direction not assertedBalancedRhea 11908

13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + NADPH + H(+)

Right to leftBalancedRhea 11912

13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

Right to leftBalancedRhea 11916

(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

Direction not assertedBalancedRhea 11920

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 11924

hydroxylamine + NH4(+) = hydrazine + H2O + H(+)

Direction not assertedBalancedRhea 11928

2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide

Direction not assertedBalancedRhea 11932

4-coumaroyl-CoA + 3 malonyl-CoA + 3 H(+) = trans-resveratrol + 4 CO2 + 4 CoA

Direction not assertedBalancedRhea 11936

L-citrulline + H2O + 2 H(+) = L-ornithine + NH4(+) + CO2

Direction not assertedBalancedRhea 11940

(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)

Direction not assertedBalancedRhea 11944

4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)

Direction not assertedBalancedRhea 11948

3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate

Direction not assertedBalancedRhea 11952

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose

Left to rightBalancedRhea 11956

N-succinyl-(2S,6S)-2,6-diaminopimelate + 2-oxoglutarate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate

Direction not assertedBalancedRhea 11960

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol

Left to rightBalancedRhea 11964

kynurenate + AH2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A

Direction not assertedBalancedRhea 11968

4 Fe(2+) + O2 + 6 H2O = 4 iron(III) oxide-hydroxide + 12 H(+)

Direction not assertedBalancedRhea 11972

anhydrotetracycline + NADPH + O2 + H(+) = 5a,11a-dehydrotetracycline + NADP(+) + H2O

Direction not assertedBalancedRhea 11976

2 gamma-L-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + NADPH + H(+)

Direction not assertedBalancedRhea 11980

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