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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,251–13,300 of 31,435, by identifier

thiamine + ATP = thiamine diphosphate + AMP + H(+)
Direction not assertedBalancedRhea 11576
a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
ReversibleBalance undeterminableRhea 11580
L-ornithine = D-ornithine
Direction not assertedBalancedRhea 11584
isoquinoline + A + H2O = isoquinolin-1(2H)-one + AH2
Direction not assertedBalancedRhea 11588
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L carboxylate + H(+)
Direction not assertedBalance undeterminableRhea 11592
orotidine 5'-phosphate + H(+) = UMP + CO2
Left to rightBalancedRhea 11596
CMP + ATP = CDP + ADP

? Direction not asserted

Balanced

Rhea 11600

[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA = [O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA

Direction not assertedBalance undeterminableRhea 11604

[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA = [N,O(9)-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA

Direction not assertedBalance undeterminableRhea 11608

L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)

Direction not assertedBalancedRhea 11612

L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + NH4(+) + H(+)

Direction not assertedBalancedRhea 11620

2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate

Direction not assertedBalancedRhea 11624

a 2-oxocarboxylate + H(+) = an aldehyde + CO2

Direction not assertedBalance undeterminableRhea 11628

L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

Left to rightBalancedRhea 11632

prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)

Left to rightBalancedRhea 11636

a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 NADH + 2 H(+)

Direction not assertedBalance undeterminableRhea 11640

a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH + 2 H(+)

Direction not assertedBalance undeterminableRhea 11644

(-)-menthol + NADPH + O2 + H(+) = 1,4-menthane-3,8-diol + NADP(+) + H2O

Direction not assertedBalancedRhea 11648

di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP

Direction not assertedBalancedRhea 11652

holo-[peptidyl-carrier protein] + L-proline + ATP = L-prolyl-[peptidyl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 11656

a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + acetate

Left to rightBalance undeterminableRhea 11660

a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = a 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)

Direction not assertedBalance undeterminableRhea 11664

[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + n phosphate + 2n H(+)

Direction not assertedBalance undeterminableRhea 11668

chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate

Direction not assertedBalancedRhea 11672

D-ribose + NADP(+) + H2O = D-ribonate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 11676

XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)

Left to rightBalancedRhea 11680

methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 11684

tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate

Left to rightBalancedRhea 11688

NAD(+) + NADPH = NADH + NADP(+)

Direction not assertedBalancedRhea 11692

3'-demethylstaurosporine + S-adenosyl-L-methionine = staurosporine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 11696

progesterone + NADPH + O2 + H(+) = testosterone acetate + NADP(+) + H2O

Direction not assertedBalancedRhea 11700

N-(carboxyaminomethyl)urea + 2 H(+) = N-(aminomethyl)urea + CO2

Direction not assertedBalancedRhea 11704

IMP + NAD(+) + H2O = XMP + NADH + H(+)

Direction not assertedBalancedRhea 11708

3-methyl-2-oxobutanoate + 2 oxidized [2Fe-2S]-[ferredoxin] + CoA = 2-methylpropanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 11712

a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)

Left to rightBalance undeterminableRhea 11716

N-methylhydantoin + ATP + 2 H2O = N-carbamoylsarcosine + ADP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 11720

[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate

Direction not assertedBalance undeterminableRhea 11724

cyclopentanol + NAD(+) = cyclopentanone + NADH + H(+)

Direction not assertedBalancedRhea 11728

sophoraflavanone B + reduced [NADPH--hemoprotein reductase] + O2 = leachianone G + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 11732

2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + NADH + H(+)

Direction not assertedBalancedRhea 11736

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

Direction not assertedBalancedRhea 11740

thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)

Direction not assertedBalancedRhea 11744

fluoroacetaldehyde + L-threonine = 4-fluoro-L-threonine + acetaldehyde

Direction not assertedBalancedRhea 11748

acetylsalicylate + H2O = salicylate + acetate + H(+)

Direction not assertedBalancedRhea 11752

biotin + L-lysyl-[protein] + ATP = N(6)-biotinyl-L-lysyl-[protein] + AMP + diphosphate + H(+)

Left to rightBalance undeterminableRhea 11756

methylguanidine + H2O = urea + methylamine

Direction not assertedBalancedRhea 11764

N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate

Direction not assertedBalancedRhea 11768

6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH + H(+)

Direction not assertedBalancedRhea 11772

octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = (9Z)-octadecenoyl-[ACP] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 11776

3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 11780

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