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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,151–13,200 of 31,435, by identifier

5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)
Direction not assertedBalancedRhea 11152
L-valine + NADP(+) + H2O = 3-methyl-2-oxobutanoate + NH4(+) + NADPH + H(+)
Direction not assertedBalancedRhea 11156
L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate
Direction not assertedBalancedRhea 11160
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)
Left to rightBalance undeterminableRhea 11164
3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + NADH + H(+)
Direction not assertedBalancedRhea 11168
(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
Left to rightBalancedRhea 11172

kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose

Direction not assertedBalancedRhea 11176

tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 11180

3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2

Left to rightBalancedRhea 11184

3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)

Direction not assertedBalancedRhea 11188

an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)

Direction not assertedBalance undeterminableRhea 11192

5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + nicotinate + H(+)

Direction not assertedBalancedRhea 11196

apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP = holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H(+)

Left to rightBalance undeterminableRhea 11204

indole + O2 = 2-formamidobenzaldehyde

Direction not assertedBalancedRhea 11212

a 2'-deoxyribonucleoside 5'-phosphate + ATP = a 2'-deoxyribonucleoside 5'-diphosphate + ADP

Direction not assertedBalance undeterminableRhea 11216

a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 11220

2 D-alanine + ATP = D-alanyl-D-alanine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 11224

(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH + H(+)

Direction not assertedBalancedRhea 11228

3'-phosphoadenylyl sulfate + H2O = sulfate + adenosine 3',5'-bisphosphate + 2 H(+)

Direction not assertedBalancedRhea 11232

putrescine + spermidine = sym-homospermidine + propane-1,3-diamine

Direction not assertedBalancedRhea 11236

thiamine diphosphate + ATP = thiamine triphosphate + ADP

Direction not assertedBalancedRhea 11240

[(3R)-hydroxybutanoate](n) + H2O = [(3R)-hydroxybutanoate](n-1) + (R)-3-hydroxybutanoate + H(+)

Direction not assertedBalance undeterminableRhea 11248

hydroxylamine + L-asparagine + H(+) = beta-L-aspartylhydroxamate + NH4(+)

Direction not assertedBalancedRhea 11252

limonin + UDP-alpha-D-glucose + H2O = limonin 17-beta-D-glucoside + UDP + 2 H(+)

Direction not assertedBalancedRhea 11256

NADPH + O2 + H(+) = H2O2 + NADP(+)

Left to rightBalancedRhea 11260

NADH + O2 + H(+) = H2O2 + NAD(+)

Direction not assertedBalancedRhea 11264

D-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+) + H(+)

Direction not assertedBalancedRhea 11268

a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol

Direction not assertedBalance undeterminableRhea 11272

4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O

Direction not assertedBalancedRhea 11276

dCMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = 5-hydroxymethyl-dCMP + (6S)-5,6,7,8-tetrahydrofolate

Direction not assertedBalancedRhea 11280

hydroxymalonate + NAD(+) = oxomalonate + NADH + H(+)

Direction not assertedBalancedRhea 11284

dihydromacarpine + O2 + H(+) = macarpine + H2O2

Direction not assertedBalancedRhea 11288

rifamycin B + O2 + 2 H(+) = rifamycin O + H2O2

Direction not assertedBalancedRhea 11292

2,5-dioxopentanoate + NADP(+) + H2O = 2-oxoglutarate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 11296

1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H(+)

Direction not assertedBalancedRhea 11300

(S)-ureidoglycolate = urea + glyoxylate

Direction not assertedBalancedRhea 11304

hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)

Left to rightBalancedRhea 11308

atrazine + H2O = hydroxyatrazine + chloride + H(+)

Direction not assertedBalancedRhea 11312

an aliphatic aldoxime = a nitrile + H2O

Direction not assertedBalance undeterminableRhea 11316

UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose

Direction not assertedBalancedRhea 11320

isopentenyl diphosphate + dimethylallyl diphosphate = neryl diphosphate + diphosphate

Direction not assertedBalancedRhea 11328

RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate

Left to rightBalance undeterminableRhea 11332

(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 11336

5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2

Direction not assertedBalancedRhea 11340

an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate

Direction not assertedBalance undeterminableRhea 11344

arsenite(in) + ATP + H2O = arsenite(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 11348

acetate + ATP = acetyl phosphate + ADP

Direction not assertedBalancedRhea 11352

A + NADH + H(+) = AH2 + NAD(+)

Direction not assertedBalancedRhea 11356

pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 11364

L-aspartate + NH4(+) + ATP = L-asparagine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 11372

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