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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,051–13,100 of 31,435, by identifier

GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + NADH + H(+)
Direction not assertedBalancedRhea 10728
firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate
Direction not assertedBalance undeterminableRhea 10732
a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)
ReversibleBalance undeterminableRhea 10736
a secondary alcohol + NAD(+) = a ketone + NADH + H(+)
Direction not assertedBalance undeterminableRhea 10740
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH
Direction not assertedBalancedRhea 10744
hydrogencarbonate + H(+) = CO2 + H2O
ReversibleBalancedRhea 10748
[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n D-aspartate + n ATP = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n phosphate + n H(+)

Direction not assertedBalance undeterminableRhea 10752

pyruvate + phosphate + ATP = phosphoenolpyruvate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 10756

citrate = oxaloacetate + acetate

Direction not assertedBalancedRhea 10760

(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + succinate + CO2 + H2O + H(+)

Direction not assertedBalancedRhea 10764

(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + succinate + CO2 + H2O + H(+)

Direction not assertedBalancedRhea 10768

6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose 6-phosphate + D-glucose

Direction not assertedBalancedRhea 10772

(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 10776

(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Right to leftBalancedRhea 10780

N(6)-methyl-L-lysyl(36)-[histone H3] + 2-oxoglutarate + O2 = L-lysyl(36)-[histone H3] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 10784

2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)

Direction not assertedBalancedRhea 10788

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2

Right to leftBalancedRhea 10792

albendazole + NADPH + O2 + H(+) = albendazole S-oxide + NADP(+) + H2O

Left to rightBalancedRhea 10796

XMP + diphosphate = xanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Direction not assertedBalancedRhea 10800

(S)-allantoin = (R)-allantoin

Direction not assertedBalancedRhea 10804

(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O

Direction not assertedBalancedRhea 10808

N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H2O = N-succinyl-L-glutamate + NADH + 2 H(+)

Direction not assertedBalancedRhea 10812

methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside + H2O = methyl beta-D-galactoside + L-fucose

Direction not assertedBalancedRhea 10816

D-threo-isocitrate = D-erythro-isocitrate

Direction not assertedBalancedRhea 10820

(S)-malate + NADP(+) = oxaloacetate + NADPH + H(+)

Direction not assertedBalancedRhea 10824

anthranilate + ATP + CoA = anthraniloyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 10828

a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 10832

O-phospho-L-homoserine + H2O = L-threonine + phosphate

Direction not assertedBalancedRhea 10840

pyridoxamine + oxaloacetate = pyridoxal + L-aspartate

Direction not assertedBalancedRhea 10844

an [alpha-factor](in) + ATP + H2O = an [alpha-factor](out) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 10848

leachianone G + dimethylallyl diphosphate = sophoraflavanone G + diphosphate

Direction not assertedBalancedRhea 10852

a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + UDP + H(+)

Direction not assertedBalance undeterminableRhea 10856

3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+)

Direction not assertedBalancedRhea 10860

3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)

Direction not assertedBalancedRhea 10864

an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

Left to rightBalance undeterminableRhea 10868

an N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate

Left to rightBalance undeterminableRhea 10872

4-hydroxybenzoate + H(+) = phenol + CO2

Direction not assertedBalancedRhea 10876

7-methylxanthosine + H2O = 7-methylxanthine + D-ribose + H(+)

Direction not assertedBalancedRhea 10880

(24R,24(1)R)-fucosterol epoxide = desmosterol + acetaldehyde

Direction not assertedBalancedRhea 10884

(2R,3S)-3-isopropylmalate + NAD(+) = (2S)-2-isopropyl-3-oxosuccinate + NADH + H(+)

Direction not assertedBalancedRhea 10892

limonin + 2 H2O = limonoate + 2 H(+)

Direction not assertedBalancedRhea 10896

an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine

Direction not assertedBalance undeterminableRhea 10900

[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + hydrogen sulfide + AH2 + CO2

Direction not assertedBalance undeterminableRhea 10904

glycolithocholate + 3'-phosphoadenylyl sulfate = glycolithocholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 10908

(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 10912

cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide

Direction not assertedBalancedRhea 10924

ent-kaur-16-en-19-al + reduced [NADPH--hemoprotein reductase] + O2 = ent-kaur-16-en-19-oate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 10928

L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 10932

6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate

Direction not assertedBalancedRhea 10936

(2E)-geranyl diphosphate = (4R)-limonene + diphosphate

Direction not assertedBalancedRhea 10940

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