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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

12,951–13,000 of 31,435, by identifier

D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)
Direction not assertedBalancedRhea 10292
D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)
Direction not assertedBalancedRhea 10296
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)
ReversibleBalancedRhea 10300
a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
Direction not assertedBalance undeterminableRhea 10304
terephthalate + NADH + O2 + H(+) = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)
Direction not assertedBalancedRhea 10312
thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2
Direction not assertedBalancedRhea 10316

trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O

Direction not assertedBalancedRhea 10320

an L-glycol + NADP(+) = a 2-hydroxycarbonyl + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 10324

an L-glycol + NAD(+) = a 2-hydroxycarbonyl + NADH + H(+)

Direction not assertedBalance undeterminableRhea 10328

a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalance undeterminableRhea 10332

citrate = D-threo-isocitrate

Direction not assertedBalancedRhea 10336

(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate

Direction not assertedBalancedRhea 10340

a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalance undeterminableRhea 10344

5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 10348

an N-acetylarylalkylamine + H2O = an aralkylamine + acetate

Direction not assertedBalance undeterminableRhea 10352

3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + NADH + H(+)

Direction not assertedBalancedRhea 10356

3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)

Direction not assertedBalancedRhea 10360

dodecanoyl-CoA + 2-oxoglutarate + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)

Direction not assertedBalancedRhea 10364

dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate

Direction not assertedBalancedRhea 10368

phenylglyoxylate + NAD(+) + CoA = benzoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 10372

Cu(2+)(in) + ATP + H2O = Cu(2+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 10376

orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate

Right to leftBalancedRhea 10380

cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = beta-cyclopiazonate + diphosphate

Direction not assertedBalancedRhea 10384

oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

ReversibleBalancedRhea 10388

(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+)

Direction not assertedBalancedRhea 10392

an L-alpha-amino acid + NAD(+) + H2O = a 2-oxocarboxylate + NH4(+) + NADH + H(+)

Direction not assertedBalance undeterminableRhea 10396

L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine

Direction not assertedBalancedRhea 10400

4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA

Right to leftBalancedRhea 10408

ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+)

Left to rightBalancedRhea 10412

toluene + fumarate = 2-benzylsuccinate

Direction not assertedBalancedRhea 10416

taurine + pyruvate = sulfoacetaldehyde + L-alanine

Direction not assertedBalancedRhea 10420

N-benzoylglycine + H2O = benzoate + glycine

Direction not assertedBalancedRhea 10424

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

Left to rightBalancedRhea 10428

2-(acetamidomethylene)succinate + 2 H2O + H(+) = succinate semialdehyde + acetate + NH4(+) + CO2

Direction not assertedBalancedRhea 10432

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O

Direction not assertedBalancedRhea 10436

D-glucono-1,5-lactone + H2O = D-gluconate + H(+)

Direction not assertedBalancedRhea 10440

(S)-reticuline + S-adenosyl-L-methionine = (S)-laudanine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 10444

a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O

Direction not assertedBalance undeterminableRhea 10448

2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + reduced [NADPH--hemoprotein reductase] + O2 = (R)-dihydrocamalexate + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 10452

D-maltose + acetyl-CoA = 1-O-acetylmaltose + CoA

Direction not assertedBalancedRhea 10456

prostaglandin A1 = prostaglandin C1

Direction not assertedBalancedRhea 10460

[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate

Direction not assertedBalance undeterminableRhea 10464

D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O

Direction not assertedBalancedRhea 10468

(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate

Direction not assertedBalancedRhea 10472

4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate

Direction not assertedBalancedRhea 10480

N-feruloylglycine + H2O = (E)-ferulate + glycine

Direction not assertedBalancedRhea 10484

(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate

Direction not assertedBalancedRhea 10488

phosphocholine + H2O = choline + phosphate

Direction not assertedBalancedRhea 10492

butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H(+)

Direction not assertedBalancedRhea 10500

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate

Right to leftBalancedRhea 10508

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