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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

12,901–12,950 of 31,435, by identifier

a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate
Direction not assertedBalance undeterminableRhea 10092
a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H(+)
Direction not assertedBalance undeterminableRhea 10096
a sterol ester + H2O = a sterol + a fatty acid + H(+)
Left to rightBalance undeterminableRhea 10100
gibberellin A20 + 2-oxoglutarate + O2 = gibberellin A1 + succinate + CO2
Direction not assertedBalancedRhea 10104
(7S)-salutaridinol + NADP(+) = salutaridine + NADPH + H(+)
Direction not assertedBalancedRhea 10108
L-homocysteine + L-serine = L,L-cystathionine + H2O
Direction not assertedBalancedRhea 10112
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH

Direction not assertedBalancedRhea 10116

adenosine in double-stranded RNA + H2O + H(+) = inosine in double-stranded RNA + NH4(+)

Left to rightBalancedRhea 10120

phenylacetone + NADPH + O2 + H(+) = benzyl acetate + NADP(+) + H2O

Direction not assertedBalancedRhea 10124

all-trans-violaxanthin = all-trans-neoxanthin

Direction not assertedBalancedRhea 10128

benzoate + ATP + CoA = benzoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 10132

2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2

Direction not assertedBalancedRhea 10136

prostaglandin F2alpha + NADP(+) = prostaglandin D2 + NADPH + H(+)

Right to leftBalancedRhea 10140

a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate

Direction not assertedBalance undeterminableRhea 10144

blasticidin S + H2O + H(+) = deaminohydroxyblasticidin S + NH4(+)

Direction not assertedBalancedRhea 10148

hydrogencarbonate + NH4(+) + ATP = carbamoyl phosphate + ADP + H2O + H(+)

Direction not assertedBalancedRhea 10152

dihydrochelirubine + reduced [NADPH--hemoprotein reductase] + O2 = 12-hydroxydihydrochelirubine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 10156

L-iditol + NAD(+) = keto-L-sorbose + NADH + H(+)

Direction not assertedBalancedRhea 10160

(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O

ReversibleBalancedRhea 10164

15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + reduced 2[4Fe-4S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 10168

(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)

Direction not assertedBalancedRhea 10172

(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H(+)

Direction not assertedBalancedRhea 10176

(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)

Left to rightBalancedRhea 10180

(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)

Direction not assertedBalancedRhea 10184

acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)

Left to rightBalancedRhea 10188

sulfate(out) + ATP + H2O = sulfate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 10192

(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O

Direction not assertedBalancedRhea 10196

butanoate + NAD(+) = (2E)-2-butenoate + NADH + H(+)

Direction not assertedBalancedRhea 10200

dimethylamine + oxidized [electron-transfer flavoprotein] + H2O + H(+) = methylamine + reduced [electron-transfer flavoprotein] + formaldehyde

Direction not assertedBalance undeterminableRhea 10204

an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)

Left to rightBalance undeterminableRhea 10208

5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate

Direction not assertedBalancedRhea 10212

[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)

Left to rightBalance undeterminableRhea 10216

tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)

Left to rightBalancedRhea 10220

pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)

Left to rightBalancedRhea 10224

citrate = cis-aconitate + H2O

Direction not assertedBalancedRhea 10228

5,6-dihydrouridine 5'-phosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate

Direction not assertedBalancedRhea 10232

trans-2-coumarate + UDP-alpha-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + UDP + H(+)

Direction not assertedBalancedRhea 10236

a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)

Direction not assertedBalance undeterminableRhea 10240

4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

Direction not assertedBalancedRhea 10244

dUTP + H2O = dUMP + diphosphate + H(+)

Direction not assertedBalancedRhea 10248

O-phospho-L-serine + hydrogen sulfide + H(+) = L-cysteine + phosphate

Direction not assertedBalancedRhea 10252

[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + n phosphate + 2n H(+)

Direction not assertedBalance undeterminableRhea 10256

Mg(2+)(out) + ATP + H2O = Mg(2+)(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 10260

alpha-D-glucose = beta-D-glucose

Direction not assertedBalancedRhea 10264

2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate

Direction not assertedBalancedRhea 10268

a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 10272

5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP

Left to rightBalancedRhea 10276

1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 10280

L-leucine = (3R)-beta-leucine

Direction not assertedBalancedRhea 10284

L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H(+)

Direction not assertedBalancedRhea 10288

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