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11,901–11,950 of 12,877 reactions from Human-GEM
PAPS[c] + taurochenodeoxycholate[c] = H+[c] + PAP[c] + Taurochenodeoxycholic acid 3-sulfate[c]
Left to rightBalancedEC 2.8.2.14Bile acid biosynthesisHuman-GEM MAR12290
ATP[c] + H2O[c] + Taurodeoxycholic acid 3-sulfate[c] = ADP[c] + H+[c] + Pi[c] + Taurodeoxycholic acid 3-sulfate[e]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12291
HCO3-[c] + Taurodeoxycholic acid 3-sulfate[e] = HCO3-[e] + Taurodeoxycholic acid 3-sulfate[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR12292
PAPS[c] + taurodeoxycholate[c] = H+[c] + PAP[c] + Taurodeoxycholic acid 3-sulfate[c]
Left to rightBalancedEC 2.8.2.14Bile acid biosynthesisHuman-GEM
ATP[c] + H2O[c] + taurohyocholic acid[c] = ADP[c] + H+[c] + Pi[c] + taurohyocholic acid[e]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12294
HCO3-[c] + taurohyocholic acid[e] = HCO3-[e] + taurohyocholic acid[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR12295
2 Na+[e] + taurohyocholic acid[e] = 2 Na+[c] + taurohyocholic acid[c]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12296
ATP[c] + H2O[c] + Tauroursodeoxycholic acid 3-sulfate[c] = ADP[c] + H+[c] + Pi[c] + Tauroursodeoxycholic acid 3-sulfate[e]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12297
HCO3-[c] + Tauroursodeoxycholic acid 3-sulfate[e] = HCO3-[e] + Tauroursodeoxycholic acid 3-sulfate[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR12298
PAPS[c] + tauroursodeoxycholate[c] = H+[c] + PAP[c] + Tauroursodeoxycholic acid 3-sulfate[c]
Left to rightBalancedEC 2.8.2.14Bile acid biosynthesisHuman-GEM MAR12299
ATP[c] + H2O[c] + ursocholic acid[c] = ADP[c] + H+[c] + Pi[c] + ursocholic acid[e]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12300
HCO3-[c] + ursocholic acid[e] = HCO3-[e] + ursocholic acid[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR12301
2 Na+[e] + ursocholic acid[e] = 2 Na+[c] + ursocholic acid[c]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12302
ATP[c] + H2O[c] + Ursodeoxycholic acid 3-sulfate[c] = ADP[c] + H+[c] + Pi[c] + Ursodeoxycholic acid 3-sulfate[e]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12303
HCO3-[c] + Ursodeoxycholic acid 3-sulfate[e] = HCO3-[e] + Ursodeoxycholic acid 3-sulfate[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR12304
PAPS[c] + ursodeoxycholate[c] = H+[c] + PAP[c] + Ursodeoxycholic acid 3-sulfate[c]
Left to rightBalancedEC 2.8.2.14Bile acid biosynthesisHuman-GEM MAR12305
HCO3-[c] + ursodeoxycholate[e] = HCO3-[e] + ursodeoxycholate[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR12306
2 Na+[e] + ursodeoxycholate[e] = 2 Na+[c] + ursodeoxycholate[c]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR12307
H+[r] + NADPH[r] + O2[r] + Tacrolimus[r] = 12-HT or M-VI, 12-hydroxy tacrolimus[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12308
ATP[c] + 12-HT or M-VI, 12-hydroxy tacrolimus[c] + H2O[c] = ADP[c] + 12-HT or M-VI, 12-hydroxy tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12309
12-HT or M-VI, 12-hydroxy tacrolimus[c] = 12-HT or M-VI, 12-hydroxy tacrolimus[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12310
13-O-desmethyl tacrolimus, 13-DMT or M-I[r] + H+[r] + SAH[r] = 13,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12311
H+[r] + SAH[r] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[r] = 13,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12312
ATP[c] + 13,31-O-Didesmethyl-tacrolimus[c] + H2O[c] = ADP[c] + 13,31-O-Didesmethyl-tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12313
13,31-O-Didesmethyl-tacrolimus[c] = 13,31-O-Didesmethyl-tacrolimus[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12314
H+[r] + SAH[r] + Tacrolimus[r] = 13-O-desmethyl tacrolimus, 13-DMT or M-I[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12315
ATP[c] + 13-O-desmethyl tacrolimus, 13-DMT or M-I[c] + H2O[c] = ADP[c] + 13-O-desmethyl tacrolimus, 13-DMT or M-I[e] + H+[c] + Pi[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12316
13-O-desmethyl tacrolimus, 13-DMT or M-I[c] = 13-O-desmethyl tacrolimus, 13-DMT or M-I[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12317
H+[r] + NADPH[r] + O2[r] + 4-OH-midazolam[r] = 1,4-Dihydroxy-midazolam[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12318
1'-OH-midazolam[r] + H+[r] + NADPH[r] + O2[r] = 1,4-Dihydroxy-midazolam[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12319
1,4-Dihydroxy-midazolam[c] = 1,4-Dihydroxy-midazolam[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12320
15-DMT or M-III, 15-O-desmethyl tacrolimus[r] + H+[r] + SAH[r] = 13,15-O-didesmethyl tacrolimus[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12321
13-O-desmethyl tacrolimus, 13-DMT or M-I[r] + H+[r] + SAH[r] = 13,15-O-didesmethyl tacrolimus[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12322
ATP[c] + 13,15-O-didesmethyl tacrolimus[c] + H2O[c] = ADP[c] + 13,15-O-didesmethyl tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12323
13,15-O-didesmethyl tacrolimus[c] = 13,15-O-didesmethyl tacrolimus[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12324
15-DMT or M-III, 15-O-desmethyl tacrolimus[r] + H+[r] + SAH[r] = 15,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12325
ATP[c] + 15,31-O-Didesmethyl-tacrolimus[c] + H2O[c] = ADP[c] + 15,31-O-Didesmethyl-tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12326
15,31-O-Didesmethyl-tacrolimus[c] = 15,31-O-Didesmethyl-tacrolimus[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12327
H+[r] + SAH[r] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[r] = 15,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12328
H+[r] + SAH[r] + Tacrolimus[r] = 15-DMT or M-III, 15-O-desmethyl tacrolimus[r] + SAM[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12329
ATP[c] + 15-DMT or M-III, 15-O-desmethyl tacrolimus[c] + H2O[c] = ADP[c] + 15-DMT or M-III, 15-O-desmethyl tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12330
15-DMT or M-III, 15-O-desmethyl tacrolimus[c] = 15-DMT or M-III, 15-O-desmethyl tacrolimus[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12331
1-hydroxy S-ibuprofen-glucuronide[c] = 1-hydroxy S-ibuprofen-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12332
1-hydroxy S-ibuprofen[r] + UDP-glucuronate[r] = 1-hydroxy S-ibuprofen-glucuronide[r] + UDP[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12333
1-hydroxy S-ibuprofen[c] = 1-hydroxy S-ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12334
1'-OH-midazolam[r] + UDP-glucuronate[r] = 1'-OH-midazolam-glucuronide[r] + H+[r] + UDP[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12335
1'-OH-midazolam-glucuronide[e] = 1'-OH-midazolam-glucuronide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12336
H+[r] + NADPH[r] + O2[r] + Midazolam[r] = 1'-OH-midazolam[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12337
1'-OH-midazolam[c] = 1'-OH-midazolam[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12338
ATP[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c] = AMP[c] + PPi[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12339