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Subsystem: Drug metabolism Remove
1–50 of 572 reactions in Drug metabolism
H+[r] + NADPH[r] + O2[r] + Tacrolimus[r] = 12-HT or M-VI, 12-hydroxy tacrolimus[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12308
ATP[c] + 12-HT or M-VI, 12-hydroxy tacrolimus[c] + H2O[c] = ADP[c] + 12-HT or M-VI, 12-hydroxy tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportHuman-GEM MAR12309
12-HT or M-VI, 12-hydroxy tacrolimus[c] = 12-HT or M-VI, 12-hydroxy tacrolimus[e]
ReversibleBalancedTransportHuman-GEM MAR12310
13-O-desmethyl tacrolimus, 13-DMT or M-I[r] + H+[r] + SAH[r] = 13,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
Left to rightBalancedHuman-GEM MAR12311
H+[r] + SAH[r] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[r] = 13,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
ATP[c] + 13,31-O-Didesmethyl-tacrolimus[c] + H2O[c] = ADP[c] + 13,31-O-Didesmethyl-tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportHuman-GEM MAR12313
13,31-O-Didesmethyl-tacrolimus[c] = 13,31-O-Didesmethyl-tacrolimus[e]
Left to rightBalancedTransportHuman-GEM MAR12314
H+[r] + SAH[r] + Tacrolimus[r] = 13-O-desmethyl tacrolimus, 13-DMT or M-I[r] + SAM[r]
Left to rightBalancedHuman-GEM MAR12315
ATP[c] + 13-O-desmethyl tacrolimus, 13-DMT or M-I[c] + H2O[c] = ADP[c] + 13-O-desmethyl tacrolimus, 13-DMT or M-I[e] + H+[c] + Pi[c]
Left to rightBalancedTransportHuman-GEM MAR12316
13-O-desmethyl tacrolimus, 13-DMT or M-I[c] = 13-O-desmethyl tacrolimus, 13-DMT or M-I[e]
ReversibleBalancedTransportHuman-GEM MAR12317
H+[r] + NADPH[r] + O2[r] + 4-OH-midazolam[r] = 1,4-Dihydroxy-midazolam[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12318
1'-OH-midazolam[r] + H+[r] + NADPH[r] + O2[r] = 1,4-Dihydroxy-midazolam[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12319
1,4-Dihydroxy-midazolam[c] = 1,4-Dihydroxy-midazolam[e]
ReversibleBalancedTransportHuman-GEM MAR12320
15-DMT or M-III, 15-O-desmethyl tacrolimus[r] + H+[r] + SAH[r] = 13,15-O-didesmethyl tacrolimus[r] + SAM[r]
Left to rightBalancedHuman-GEM MAR12321
13-O-desmethyl tacrolimus, 13-DMT or M-I[r] + H+[r] + SAH[r] = 13,15-O-didesmethyl tacrolimus[r] + SAM[r]
Left to rightBalancedHuman-GEM MAR12322
ATP[c] + 13,15-O-didesmethyl tacrolimus[c] + H2O[c] = ADP[c] + 13,15-O-didesmethyl tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportHuman-GEM MAR12323
13,15-O-didesmethyl tacrolimus[c] = 13,15-O-didesmethyl tacrolimus[e]
ReversibleBalancedTransportHuman-GEM MAR12324
15-DMT or M-III, 15-O-desmethyl tacrolimus[r] + H+[r] + SAH[r] = 15,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
Left to rightBalancedHuman-GEM MAR12325
ATP[c] + 15,31-O-Didesmethyl-tacrolimus[c] + H2O[c] = ADP[c] + 15,31-O-Didesmethyl-tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportHuman-GEM MAR12326
15,31-O-Didesmethyl-tacrolimus[c] = 15,31-O-Didesmethyl-tacrolimus[e]
Left to rightBalancedTransportHuman-GEM MAR12327
H+[r] + SAH[r] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[r] = 15,31-O-Didesmethyl-tacrolimus[r] + SAM[r]
Left to rightBalancedHuman-GEM MAR12328
H+[r] + SAH[r] + Tacrolimus[r] = 15-DMT or M-III, 15-O-desmethyl tacrolimus[r] + SAM[r]
Left to rightBalancedHuman-GEM MAR12329
ATP[c] + 15-DMT or M-III, 15-O-desmethyl tacrolimus[c] + H2O[c] = ADP[c] + 15-DMT or M-III, 15-O-desmethyl tacrolimus[e] + H+[c] + Pi[c]
Left to rightBalancedTransportHuman-GEM MAR12330
15-DMT or M-III, 15-O-desmethyl tacrolimus[c] = 15-DMT or M-III, 15-O-desmethyl tacrolimus[e]
ReversibleBalancedTransportHuman-GEM MAR12331
1-hydroxy S-ibuprofen-glucuronide[c] = 1-hydroxy S-ibuprofen-glucuronide[e]
ReversibleBalancedTransportHuman-GEM MAR12332
1-hydroxy S-ibuprofen[r] + UDP-glucuronate[r] = 1-hydroxy S-ibuprofen-glucuronide[r] + UDP[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12333
1-hydroxy S-ibuprofen[c] = 1-hydroxy S-ibuprofen[e]
ReversibleBalancedTransportHuman-GEM MAR12334
1'-OH-midazolam[r] + UDP-glucuronate[r] = 1'-OH-midazolam-glucuronide[r] + H+[r] + UDP[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12335
1'-OH-midazolam-glucuronide[e] = 1'-OH-midazolam-glucuronide[c]
ReversibleBalancedTransportHuman-GEM MAR12336
H+[r] + NADPH[r] + O2[r] + Midazolam[r] = 1'-OH-midazolam[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12337
1'-OH-midazolam[c] = 1'-OH-midazolam[e]
ReversibleBalancedTransportHuman-GEM MAR12338
ATP[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c] = AMP[c] + PPi[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c]
Left to rightBalancedHuman-GEM MAR12339
UDP-glucuronate[r] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[r] = UDP[r] + 2-hydroxy-atorvastatin-acyl-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12340
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-acyl-glucuronide[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-acyl-glucuronide[e]
Left to rightBalancedTransportHuman-GEM MAR12341
H+[r] + NADPH[r] + O2[r] + atorvastatin-acid[r] = H2O[r] + NADP+[r] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12342
H2O[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c] = H+[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c]
Left to rightBalancedEC 3.1.1.2Human-GEM MAR12343
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[e]
Left to rightBalancedTransportHuman-GEM MAR12344
2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c] = 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[e]
ReversibleBalancedTransportHuman-GEM MAR12345
HCO3-[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[e] = HCO3-[e] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c]
ReversibleBalancedTransportHuman-GEM MAR12346
UDP-glucuronate[r] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[r] = H+[r] + UDP[r] + 2-hydroxy-atorvastatin-lactone-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12347
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-lactone-glucuronide[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-lactone-glucuronide[e]
Left to rightBalancedTransportHuman-GEM MAR12348
H+[r] + NADPH[r] + O2[r] + atorvastatin-lactone[r] = H2O[r] + NADP+[r] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12349
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[e]
Left to rightBalancedTransportHuman-GEM MAR12350
2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c] = 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[e]
ReversibleBalancedTransportHuman-GEM MAR12351
HCO3-[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[e] = HCO3-[e] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c]
ReversibleBalancedTransportHuman-GEM MAR12352
2-hydroxy S-ibuprofen-glucuronide[c] = 2-hydroxy S-ibuprofen-glucuronide[e]
ReversibleBalancedTransportHuman-GEM MAR12353
2-hydroxy-R-ibuprofen[c] = 2-hydroxy-R-ibuprofen[e]
ReversibleBalancedTransportHuman-GEM MAR12354
UDP-glucuronate[r] + 2-hydroxy-S-ibuprofen[r] = UDP[r] + 2-hydroxy S-ibuprofen-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12355
2-hydroxy-S-ibuprofen[c] = 2-hydroxy-S-ibuprofen[e]
ReversibleBalancedTransportHuman-GEM MAR12356
H+[r] + SAH[r] + Tacrolimus[r] = SAM[r] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[r]
Left to rightBalancedHuman-GEM MAR12357