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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

11,451–11,500 of 18,558 reactions from Rhea

(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)
Direction not assertedBalancedRhea 58052
hypotaurine + pyruvate = 2-sulfinoacetaldehyde + L-alanine
Direction not assertedBalancedRhea 58056
2-sulfinoacetaldehyde + H2O = acetaldehyde + sulfite + H(+)
Direction not assertedBalancedRhea 58060
xanthotoxin + reduced [NADPH--hemoprotein reductase] + O2 = 5-hydroxyxanthotoxin + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 58064
(E)-isoeugenol + O2 = vanillin + acetaldehyde
Direction not assertedBalancedRhea 58068
a 4,5-didehydrojasmonate + NADPH + H(+) = a jasmonate + NADP(+)
Direction not assertedBalancedRhea 58072
1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)

Direction not assertedBalancedRhea 58076

1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)

Direction not assertedBalancedRhea 58080

1-(13Z-docosenoyl)-glycerol + H2O = (13Z)-docosenoate + glycerol + H(+)

Direction not assertedBalancedRhea 58084

1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)

Direction not assertedBalancedRhea 58088

1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)

Direction not assertedBalancedRhea 58092

1-tetracosanoylglycerol + H2O = tetracosanoate + glycerol + H(+)

Direction not assertedBalancedRhea 58096

1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)

Direction not assertedBalancedRhea 58100

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate

Direction not assertedBalancedRhea 58104

N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate

Left to rightBalance undeterminableRhea 58108

1''-O-acetyl-ADP-alpha-D-ribose + H2O = ADP-D-ribose + acetate + H(+)

Left to rightBalancedRhea 58112

L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 58116

L-seryl-[protein] + ATP = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate

Left to rightBalance undeterminableRhea 58120

(19E)-geissoschizine + reduced [NADPH--hemoprotein reductase] + O2 = polyneuridine aldehyde + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 58124

tetrahydroalstonine + A + reduced [NADPH--hemoprotein reductase] + O2 = alstonine + AH2 + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 58128

ajmalicine + A + reduced [NADPH--hemoprotein reductase] + O2 = serpentine + AH2 + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 58132

acetate + ATP + H(+) = acetyl-AMP + diphosphate

Direction not assertedBalancedRhea 58136

acetyl-AMP + cytidine(34) in elongator tRNA(Met) = N(4)-acetylcytidine(34) in elongator tRNA(Met) + AMP + H(+)

Direction not assertedBalancedRhea 58140

cytidine(34) in elongator tRNA(Met) + acetate + ATP = N(4)-acetylcytidine(34) in elongator tRNA(Met) + AMP + diphosphate

Direction not assertedBalancedRhea 58144

ethyl acetate + H2O = ethanol + acetate + H(+)

Direction not assertedBalancedRhea 58148

phosphonoacetaldehyde + NAD(+) + H2O = phosphonoacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 58152

4 Na(+)(in) + ATP + H2O = 4 Na(+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 58156

ent-copalyl diphosphate = dolabradiene + diphosphate

Direction not assertedBalancedRhea 58160

(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate

Direction not assertedBalancedRhea 58164

(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate

Direction not assertedBalancedRhea 58168

(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate

Direction not assertedBalancedRhea 58172

2 (2E,6E,10E)-geranylgeranyl diphosphate + NADPH + H(+) = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)

Direction not assertedBalancedRhea 58176

(1R,2R,3R)-prephytoene diphosphate + NADPH + H(+) = all-trans-lycopaoctaene + diphosphate + NADP(+)

Direction not assertedBalancedRhea 58180

2 phytyl diphosphate + NADPH + H(+) = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)

Direction not assertedBalancedRhea 58184

all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate

Direction not assertedBalancedRhea 58188

isopentenyldehydrorhodopin + dimethylallyl diphosphate + H2O = dihydrobisanhydrobacterioruberin + diphosphate

Direction not assertedBalancedRhea 58192

N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate

Left to rightBalance undeterminableRhea 58196

6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate

Direction not assertedBalancedRhea 58200

tetrahydroalstonine + reduced [NADPH--hemoprotein reductase] + O2 = dihydroalstonine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 58204

dihydroalstonine + A = alstonine + AH2

Direction not assertedBalancedRhea 58208

ajmalicine + reduced [NADPH--hemoprotein reductase] + O2 = dihydroserpentine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 58212

dihydroserpentine + A = serpentine + AH2

Direction not assertedBalancedRhea 58216

L-lysyl-[protein] + NAD(+) = N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 58220

L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide

Left to rightBalance undeterminableRhea 58224

L-asparaginyl-[protein] + NAD(+) = N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 58228

L-seryl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-seryl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 58232

L-tyrosyl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-tyrosyl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 58236

S-(ADP-D-ribosyl)-L-cysteinyl-[protein] + H2O = ADP-D-ribose + L-cysteinyl-[protein]

Direction not assertedBalance undeterminableRhea 58240

N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + H2O = ADP-D-ribose + L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 58244

5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-D-ribose + H(+)

Left to rightBalance undeterminableRhea 58248

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