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Proteins/UNIPROT:Q8N5A5
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis..
[Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA..
Function from UniProtKB (Q8N5A5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
39 statements
39 statements · 2 reference databases · Subject: ZGPAT · Sources: gene ontology, Hetionet
9 names
Resolves to: ZGPAT