young-onset Parkinson disease
Findings
No curated finding names young-onset Parkinson disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
Definition from the Mondo Disease Ontology (MONDO:0017279), read 2026-09-29. CC BY 4.0.
Features
34 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- RigidityHPOHP:0002063
- Very frequent (80% to 99% of cases)
- ApathyHPOHP:0000741
- Frequent (30% to 79% of cases)
- DepressionHPOHP:0000716
- Frequent (30% to 79% of cases)
- DyskinesiaHPOHP:0100660
- Frequent (30% to 79% of cases)
- HallucinationsHPOHP:0000738
- Frequent (30% to 79% of cases)
- Postural instabilityHPOHP:0002172
- Frequent (30% to 79% of cases)
- TremorHPOHP:0001337
- Frequent (30% to 79% of cases)
- Abnormal autonomic nervous system physiologyHPOHP:0012332
- Occasional (5% to 29% of cases)
- AnxietyHPOHP:0000739
- Occasional (5% to 29% of cases)
- BradykinesiaHPOHP:0002067
- Occasional (5% to 29% of cases)
- Cognitive impairmentHPOHP:0100543
- Occasional (5% to 29% of cases)
- Color vision defectHPOHP:0000551
- Occasional (5% to 29% of cases)
Show the remaining 22
- ConstipationHPOHP:0002019
- Occasional (5% to 29% of cases)
- DementiaHPOHP:0000726
- Occasional (5% to 29% of cases)
- DiarrheaHPOHP:0002014
- Occasional (5% to 29% of cases)
- DystoniaHPOHP:0001332
- Occasional (5% to 29% of cases)
- Female sexual dysfunctionHPOHP:0030014
- Occasional (5% to 29% of cases)
- Gait imbalanceHPOHP:0002141
- Occasional (5% to 29% of cases)
Genes
7 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- DNAJC6HGNC:15469
- Supportive · Orphanet · Autosomal recessive · 2021
- PARK7HGNC:16369
- Supportive · Orphanet · Autosomal recessive · 2021
- PINK1HGNC:14581
- Supportive · Orphanet · Autosomal recessive · 2021
- PODXLHGNC:9171
- Supportive · Orphanet · Autosomal recessive · 2021
- PRKNHGNC:8607
- Supportive · Orphanet · Autosomal recessive · 2021
Where it sits
- A kind of
- Narrower terms (9)
- autosomal recessive early-onset Parkinson disease 23
- autosomal recessive early-onset Parkinson disease 6
- autosomal recessive early-onset Parkinson disease 7
- autosomal recessive juvenile Parkinson disease 2
- early-onset Parkinson disease 20
- juvenile-onset Parkinson disease
- Parkinson disease 10
- Parkinson disease 12
- Parkinson disease 3, autosomal dominant
Other names
2 names
Resolves to: young-onset Parkinson disease
- Also called
- early-onset Parkinson diseaseYOPD