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Proteins/UNIPROT:Q70EK9
Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1..
Function from UniProtKB (Q70EK9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
16 statements
16 statements · 2 reference databases · Subject: USP51 · Sources: gene ontology, Hetionet
1 reaction
3 names
Resolves to: USP51
Human-GEM MAR09490CC BY 4.0Reference data