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Proteins/UNIPROT:Q6IPR3
S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of wybutosine, a hyper modified guanosine with a tricyclic base located at position 37 of eukaryotic phenylalanine tRNA (tRNA(Phe)) that contributes to maintenance of the translational reading frame. Catalyzes the methylation of 4-demethylwyosine, generating intermediates required for the formation of mature wybutosine..
Function from UniProtKB (Q6IPR3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 2 reference databases · Subject: TYW3 · Sources: Hetionet, Reactome
1 reaction
4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe)+S-adenosyl-L-methionine7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe)+S-adenosyl-L-homocysteine+hydron
Catalysed by TYW3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36635CC BY 4.0Reference data
3 names
Resolves to: TYW3