Proteins/UNIPROT:Q8TBZ3

WDR20

ProteinUNIPROT:Q8TBZ3

Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme. Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus..

Function from UniProtKB (Q8TBZ3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 3 reference databases · Subject: WDR20 · Sources: gene ontology, Hetionet, Reactome

Order

SIN3B covaries with WDR20ProteinHetionet hetionet:covaries:23309-91833Inferred only
LIG4 interacts with WDR20ProteinHetionet hetionet:interacts:3981-91833Inferred only
UBC interacts with WDR20ProteinHetionet hetionet:interacts:7316-91833Inferred only
USP46 interacts with WDR20ProteinHetionet hetionet:interacts:64854-91833Inferred only
WDR48 interacts with WDR20ProteinHetionet hetionet:interacts:57599-91833Inferred only
WDR20 participates in DeubiquitinationPathwayReactome R-HSA-5688426Inferred only
WDR20 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
WDR20 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
WDR20 participates in Ub-specific processing proteasesPathwayReactome R-HSA-5689880Inferred only
WDR20 regulates negative regulation of ubiquitin-dependent protein catabolic processBiological processgene ontology Q8TBZ3|GO:2000059Inferred only
WDR20 regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology Q8TBZ3|GO:0090263Inferred only

Other names

3 names

Resolves to: WDR20

Also called: DMRProtein DMRWD repeat-containing protein 20

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