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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q70EL2

USP45

Protein·UNIPROT:Q70EL2

Open in the graph

Catalyzes the deubiquitination of SPDL1. Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites. May be involved in the maintenance of photoreceptor function. May play a role in normal retinal development (By similarity). Plays a role in cell migration..

Function from UniProtKB (Q70EL2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

Leber congenital amaurosis has a germline basis in USP45DiseaseGenCC HGNC:20080|MONDO:0018998Inferred only
Leber congenital amaurosis 19 has a germline basis in USP45DiseaseGenCC HGNC:20080|MONDO:0032794Inferred only

Statements

2 statements

2 statements · 1 reference database · Subject: USP45 · Sources: Hetionet

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USP45 covaries with ASPGProteinHetionet hetionet:covaries:374569-85015Inferred only
UBC interacts with USP45ProteinHetionet hetionet:interacts:7316-85015Inferred only

Reactions

1 reaction

water+MAM03104cproton+a thiol+MAM03105c
Catalysed by USP2 or USP28 or USP36 or USP13 or OTUD5 or USP33 or CYLD or USP40 or USP48 or USP14 or USP10 or USP31 and 43 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: USP45

Also called: Deubiquitinating enzyme 45Ubiquitin thioesterase 45Ubiquitin-specific-processing protease 45

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EC 3.4.19.12

GO:0005829

Human-GEM MAR09490CC BY 4.0Reference data