Proteins/UNIPROT:Q9Y6N9

USH1C

ProteinUNIPROT:Q9Y6N9

Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips..

Function from UniProtKB (Q9Y6N9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

autosomal recessive nonsyndromic hearing loss 18A has a germline basis in USH1CDiseaseGenCC HGNC:12597|MONDO:0011192Inferred only
hearing loss, autosomal recessive has a germline basis in USH1CDiseaseGenCC HGNC:12597|MONDO:0019588Inferred only
Usher syndrome type 1 has a germline basis in USH1CDiseaseGenCC HGNC:12597|MONDO:0010168Inferred only
Usher syndrome type 1C has a germline basis in USH1CDiseaseGenCC HGNC:12597|MONDO:0010171Inferred only

Statements

18 statements

18 statements · 4 reference databases · Subject: USH1C · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

PRR7 covaries with USH1CProteinHetionet hetionet:covaries:10083-80758Inferred only
SNORC covaries with USH1CProteinHetionet hetionet:covaries:10083-389084Inferred only
ZSWIM4 covaries with USH1CProteinHetionet hetionet:covaries:10083-65249Inferred only
USH1C interacts with ANKS4BProteinHetionet hetionet:interacts:10083-257629Inferred only
USH1C interacts with CDH23ProteinHetionet hetionet:interacts:10083-64072Inferred only
MYO7A interacts with USH1CProteinHetionet hetionet:interacts:10083-4647Inferred only
QKI interacts with USH1CProteinHetionet hetionet:interacts:10083-9444Inferred only
USH1C interacts with USH1GProteinHetionet hetionet:interacts:10083-124590Inferred only
USH1C interacts with USHBP1ProteinHetionet hetionet:interacts:10083-83878Inferred only
USH1C participates in 5q35 copy number variationPathwayWikiPathways WP5380Inferred only
USH1C participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
USH1C participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only

Show the remaining 6

USH1C participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
USH1C participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
USH1C participates in Sensory processing of sound by outer hair cells of the cochleaPathwayReactome R-HSA-9662361Inferred only
USH1C regulates regulation of microvillus lengthBiological processgene ontology Q9Y6N9|GO:0032532Inferred only
CTSL increases the expression of USH1CProteinHetionet hetionet:regulates:1514-10083Inferred only
NCOA3 increases the expression of USH1CProteinHetionet hetionet:regulates:8202-10083Inferred only

Other names

7 names

Resolves to: USH1C

Also called: AIE75Antigen NY-CO-38/NY-CO-37Autoimmune enteropathy-related antigen AIE-75PDZ-73Protein PDZ-73Renal carcinoma antigen NY-REN-3Usher syndrome type-1C protein

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