Proteins/UNIPROT:Q9H251

CDH23

ProteinUNIPROT:Q9H251

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing..

Function from UniProtKB (Q9H251), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

autosomal recessive nonsyndromic hearing loss 12 has a germline basis in CDH23DiseaseGenCC HGNC:13733|MONDO:0011067Inferred only
hearing loss, autosomal recessive has a germline basis in CDH23DiseaseGenCC HGNC:13733|MONDO:0019588Inferred only
nonsyndromic genetic hearing loss has a germline basis in CDH23DiseaseGenCC HGNC:13733|MONDO:0019497Inferred only
Usher syndrome type 1 has a germline basis in CDH23DiseaseGenCC HGNC:13733|MONDO:0010168Inferred only
Usher syndrome type 1D has a germline basis in CDH23DiseaseGenCC HGNC:13733|MONDO:0010984Inferred only

Statements

30 statements

30 statements · 4 reference databases · Subject: CDH23 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ABCA2 covaries with CDH23ProteinHetionet hetionet:covaries:20-64072Inferred only
ASPDH covaries with CDH23ProteinHetionet hetionet:covaries:554235-64072Inferred only
BICDL1 covaries with CDH23ProteinHetionet hetionet:covaries:64072-92558Inferred only
CDH23 covaries with CDCP2ProteinHetionet hetionet:covaries:200008-64072Inferred only
CDH23 covaries with CHIAProteinHetionet hetionet:covaries:27159-64072Inferred only
CIMIP2A covaries with CDH23ProteinHetionet hetionet:covaries:401565-64072Inferred only
CLEC2L covaries with CDH23ProteinHetionet hetionet:covaries:154790-64072Inferred only
CYSRT1 covaries with CDH23ProteinHetionet hetionet:covaries:375791-64072Inferred only
FRAT2 covaries with CDH23ProteinHetionet hetionet:covaries:23401-64072Inferred only
FSCN2 covaries with CDH23ProteinHetionet hetionet:covaries:25794-64072Inferred only
H2BC1 covaries with CDH23ProteinHetionet hetionet:covaries:255626-64072Inferred only
CDH23 covaries with HTR1DProteinHetionet hetionet:covaries:3352-64072Inferred only

Show the remaining 18

KCTD11 covaries with CDH23ProteinHetionet hetionet:covaries:147040-64072Inferred only
MAPK7 covaries with CDH23ProteinHetionet hetionet:covaries:5598-64072Inferred only
NHERF2 covaries with CDH23ProteinHetionet hetionet:covaries:64072-9351Inferred only
OBSCN covaries with CDH23ProteinHetionet hetionet:covaries:64072-84033Inferred only
OR52H1 covaries with CDH23ProteinHetionet hetionet:covaries:390067-64072Inferred only
OR6S1 covaries with CDH23ProteinHetionet hetionet:covaries:341799-64072Inferred only
RPS16 covaries with CDH23ProteinHetionet hetionet:covaries:6217-64072Inferred only
WBP2 covaries with CDH23ProteinHetionet hetionet:covaries:23558-64072Inferred only
XKR6 covaries with CDH23ProteinHetionet hetionet:covaries:286046-64072Inferred only
ZYX covaries with CDH23ProteinHetionet hetionet:covaries:64072-7791Inferred only
MYO7A interacts with CDH23ProteinHetionet hetionet:interacts:4647-64072Inferred only
USH1C interacts with CDH23ProteinHetionet hetionet:interacts:10083-64072Inferred only
CDH23 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
CDH23 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
CDH23 participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
CDH23 participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
CDH23 participates in Sensory processing of sound by outer hair cells of the cochleaPathwayReactome R-HSA-9662361Inferred only
CDH23 regulates regulation of cytosolic calcium ion concentrationBiological processgene ontology Q9H251|GO:0051480Inferred only

Other names

4 names

Resolves to: CDH23

Also called: Cadherin-23KIAA1774KIAA1812Otocadherin

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