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Proteins/UNIPROT:Q9Y5Z9
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress..
Function from UniProtKB (Q9Y5Z9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
37 statements
37 statements · 5 reference databases · Subject: UBIAD1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
CHEBI:16856+trans-urocanateMAM02866c
Reaction pageReversibleBalancedEC 2.5.1.-cytosol
Human-GEM MAR05337CC BY 4.0Reference data
(2E,6E,10E)-geranylgeranyl diphosphate+menadioldiphosphate(3-)+MAM20066c
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.M22cytosol
2 names
Resolves to: UBIAD1
(2E,6E,10E)-geranylgeranyl diphosphate+menadioldiphosphate(3-)+MAM20066r
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.M22endoplasmic reticulum
Human-GEM MAR20103CC BY 4.0Reference data
(2E,6E,10E)-geranylgeranyl diphosphate+menadioldiphosphate(3-)+MAM20066g
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.M22Golgi apparatus
Human-GEM MAR20104CC BY 4.0Reference data
(2E,6E,10E)-geranylgeranyl diphosphate+menadioldiphosphate(3-)+MAM20066n
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.M22nucleus
Human-GEM MAR20105CC BY 4.0Reference data
4-hydroxybenzoate+all-trans-decaprenyl diphosphate4-hydroxy-3-(all-trans-decaprenyl)benzoate+diphosphate(3-)
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.39cytosol
Human-GEM MAR20106CC BY 4.0Reference data
4-hydroxybenzoate+all-trans-decaprenyl diphosphate4-hydroxy-3-(all-trans-decaprenyl)benzoate+diphosphate(3-)
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.39endoplasmic reticulum
Human-GEM MAR20107CC BY 4.0Reference data
4-hydroxybenzoate+all-trans-decaprenyl diphosphate4-hydroxy-3-(all-trans-decaprenyl)benzoate+diphosphate(3-)
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.39Golgi apparatus
Human-GEM MAR20108CC BY 4.0Reference data
4-hydroxybenzoate+all-trans-decaprenyl diphosphate4-hydroxy-3-(all-trans-decaprenyl)benzoate+diphosphate(3-)
Catalysed by UBIAD1
Reaction pageLeft to rightBalancedEC 2.5.1.39nucleus
Human-GEM MAR20109CC BY 4.0Reference data
all-trans-decaprenyl diphosphate+4-hydroxybenzoate4-hydroxy-3-(all-trans-decaprenyl)benzoate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:44564CC BY 4.0Reference data
menadiol+(2E,6E,10E)-geranylgeranyl diphosphateCHEBI:193091+diphosphate(3-)
Catalysed by UBIAD1
Reaction pageLeft to rightBalanced
Rhea RHEA:74083CC BY 4.0Reference data