Schnyder corneal dystrophy
Findings
No curated finding names Schnyder corneal dystrophy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Schnyder corneal dystrophy (SCD) is a rare form of stromal corneal dystrophy characterized by corneal clouding or crystals within the corneal stroma, and a progressive decrease in visual acuity.
Definition from the Mondo Disease Ontology (MONDO:0007374), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Juvenile onset · Young adult onset · Childhood onset
HPO, annotations 2026-09-02
Features
3 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Central opacification of the corneaHPOHP:0011493
- Corneal arcusHPOHP:0001084
- Young adult onset
- Reduced visual acuityHPOHP:0007663
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- UBIAD1HGNC:30791
- Definitive · G2P · Autosomal dominant · 2017
- Strong · Ambry Genetics · Autosomal dominant · 2024
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2023
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
7 names
Resolves to: Schnyder corneal dystrophy
- Also called
- corneal dystrophy, Schnyder typecrystalline stromal dystrophyhereditary crystalline stromal dystrophy of SchnyderSCCDSCDSchnyder crystalline corneal dystrophySchnyder crystalline dystrophy sine crystals