Proteins/UNIPROT:Q15643

TRIP11

ProteinUNIPROT:Q15643

Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription..

Function from UniProtKB (Q15643), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

achondrogenesis type IA has a germline basis in TRIP11DiseaseGenCC HGNC:12305|MONDO:0008701Inferred only
TRIP11-related skeletal dysplasia has a germline basis in TRIP11DiseaseGenCC HGNC:12305|MONDO:1040009Inferred only

Statements

31 statements

31 statements · 2 reference databases · Subject: TRIP11 · Sources: Hetionet, Reactome

Order

ACTG1 covaries with TRIP11ProteinHetionet hetionet:covaries:71-9321Inferred only
AP1M2 covaries with TRIP11ProteinHetionet hetionet:covaries:10053-9321Inferred only
BRAT1 covaries with TRIP11ProteinHetionet hetionet:covaries:221927-9321Inferred only
BTBD2 covaries with TRIP11ProteinHetionet hetionet:covaries:55643-9321Inferred only
C6orf120 covaries with TRIP11ProteinHetionet hetionet:covaries:387263-9321Inferred only
COX19 covaries with TRIP11ProteinHetionet hetionet:covaries:90639-9321Inferred only
TRIP11 covaries with FKBP2ProteinHetionet hetionet:covaries:2286-9321Inferred only
KDELR1 covaries with TRIP11ProteinHetionet hetionet:covaries:10945-9321Inferred only
SH3BP4 covaries with TRIP11ProteinHetionet hetionet:covaries:23677-9321Inferred only
SUMO3 covaries with TRIP11ProteinHetionet hetionet:covaries:6612-9321Inferred only
TBC1D16 covaries with TRIP11ProteinHetionet hetionet:covaries:125058-9321Inferred only
TIGD5 covaries with TRIP11ProteinHetionet hetionet:covaries:84948-9321Inferred only

Show the remaining 19

TRIP11 interacts with ATXN1LProteinHetionet hetionet:interacts:342371-9321Inferred only
MYBPC2 interacts with TRIP11ProteinHetionet hetionet:interacts:4606-9321Inferred only
TRIP11 interacts with PCLAFProteinHetionet hetionet:interacts:9321-9768Inferred only
PSMC5 interacts with TRIP11ProteinHetionet hetionet:interacts:5705-9321Inferred only
RB1 interacts with TRIP11ProteinHetionet hetionet:interacts:5925-9321Inferred only
THRA interacts with TRIP11ProteinHetionet hetionet:interacts:7067-9321Inferred only
UBC interacts with TRIP11ProteinHetionet hetionet:interacts:7316-9321Inferred only
TRIP11 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
TRIP11 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
TRIP11 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
TRIP11 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
TRIP11 participates in FLT3 signaling in diseasePathwayReactome R-HSA-9682385Inferred only
TRIP11 participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
TRIP11 participates in Intra-Golgi trafficPathwayReactome R-HSA-6811438Inferred only
TRIP11 participates in Intraflagellar transportPathwayReactome R-HSA-5620924Inferred only
TRIP11 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
TRIP11 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
TRIP11 participates in Signaling by FLT3 fusion proteinsPathwayReactome R-HSA-9703465Inferred only
TRIP11 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

7 names

Resolves to: TRIP11

Also called: CEV14Clonal evolution-related gene on chromosome 14 proteinGMAP-210Golgi-associated microtubule-binding protein 210TR-interacting protein 11TRIP-11Trip230

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