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Proteins/UNIPROT:Q8WZ04
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity)..
Function from UniProtKB (Q8WZ04), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 3 reference databases · Subject: TOMT · Sources: Hetionet, Reactome, Rhea
1 reaction
a catechol+S-adenosyl-L-methioninea guaiacol+S-adenosyl-L-homocysteine+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17877CC BY 4.0Reference data
5 names
Resolves to: TOMT