Pathway

Dopamine clearance from the synaptic cleft

The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Gu et al., 1994; Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.

Summary from Reactome (R-HSA-379401), read 2026-09-23.

REACT:R-HSA-379401Reactome

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What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: Dopamine clearance from the synaptic cleft · Sources: Reactome

Order

COMT participates in Dopamine clearance from the synaptic cleftProteinReactome R-HSA-379401Inferred only
MAOA participates in Dopamine clearance from the synaptic cleftProteinReactome R-HSA-379401Inferred only
SLC6A3 participates in Dopamine clearance from the synaptic cleftProteinReactome R-HSA-379401Inferred only
TOMT participates in Dopamine clearance from the synaptic cleftProteinReactome R-HSA-379401Inferred only