Proteins/UNIPROT:P45379

TNNT2

ProteinUNIPROT:P45379

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Function from UniProtKB (P45379), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

6 rows

cardiomyopathy, familial restrictive, 3 has a germline basis in TNNT2DiseaseGenCC HGNC:11949|MONDO:0012900Inferred only
dilated cardiomyopathy 1D has a germline basis in TNNT2DiseaseGenCC HGNC:11949|MONDO:0011095Inferred only
familial isolated dilated cardiomyopathy has a germline basis in TNNT2DiseaseGenCC HGNC:11949|MONDO:0700335Inferred only
hypertrophic cardiomyopathy 2 has a germline basis in TNNT2DiseaseGenCC HGNC:11949|MONDO:0007266Inferred only
hypertrophic cardiomyopathy 3 has a germline basis in TNNT2DiseaseGenCC HGNC:11949|MONDO:0007267Inferred only
left ventricular noncompaction has a germline basis in TNNT2DiseaseGenCC HGNC:11949|MONDO:0018901Inferred only

Statements

27 statements

27 statements · 4 reference databases · Subject: TNNT2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

APOBEC3H covaries with TNNT2ProteinHetionet hetionet:covaries:164668-7139Inferred only
TNNT2 covaries with CTBSProteinHetionet hetionet:covaries:1486-7139Inferred only
CYB5R1 covaries with TNNT2ProteinHetionet hetionet:covaries:51706-7139Inferred only
TNNT3 covaries with TNNT2ProteinHetionet hetionet:covaries:7139-7140Inferred only
APP interacts with TNNT2ProteinHetionet hetionet:interacts:351-7139Inferred only
MAP3K5 interacts with TNNT2ProteinHetionet hetionet:interacts:4217-7139Inferred only
PRKCA interacts with TNNT2ProteinHetionet hetionet:interacts:5578-7139Inferred only
TNNC1 interacts with TNNT2ProteinHetionet hetionet:interacts:7134-7139Inferred only
TNNI1 interacts with TNNT2ProteinHetionet hetionet:interacts:7135-7139Inferred only
TNNI3 interacts with TNNT2ProteinHetionet hetionet:interacts:7137-7139Inferred only
TNNT2 interacts with TPM1ProteinHetionet hetionet:interacts:7139-7168Inferred only
TNNT2 interacts with UBCProteinHetionet hetionet:interacts:7139-7316Inferred only

Show the remaining 15

TNNT2 participates in Caffeine in myocytesPathwayWikiPathways WP5603Inferred only
TNNT2 participates in Cardiac progenitor differentiationPathwayWikiPathways WP2406Inferred only
TNNT2 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
TNNT2 participates in Striated Muscle ContractionPathwayReactome R-HSA-390522Inferred only
TNNT2 participates in Striated muscle contraction pathwayPathwayWikiPathways WP383Inferred only
TNNT2 regulates negative regulation of ATP-dependent activityBiological processgene ontology P45379|GO:0032780Inferred only
TNNT2 regulates positive regulation of ATP-dependent activityBiological processgene ontology P45379|GO:0032781Inferred only
TNNT2 regulates regulation of heart contractionBiological processgene ontology P45379|GO:0008016Inferred only
TNNT2 regulates regulation of muscle contractionBiological processgene ontology P45379|GO:0006937Inferred only
ABCC5 decreases the expression of TNNT2ProteinHetionet hetionet:regulates:10057-7139Inferred only
DYRK3 increases the expression of TNNT2ProteinHetionet hetionet:regulates:8444-7139Inferred only
MAP4K4 increases the expression of TNNT2ProteinHetionet hetionet:regulates:9448-7139Inferred only
MYOD1 increases the expression of TNNT2ProteinHetionet hetionet:regulates:4654-7139Inferred only
SKIC2 increases the expression of TNNT2ProteinHetionet hetionet:regulates:6499-7139Inferred only
STK33 increases the expression of TNNT2ProteinHetionet hetionet:regulates:65975-7139Inferred only

Other names

3 names

Resolves to: TNNT2

Also called: Cardiac muscle troponin TcTnTTnTc

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