Proteins/UNIPROT:P63316

TNNC1

ProteinUNIPROT:P63316

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Function from UniProtKB (P63316), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

dilated cardiomyopathy 1Z has a germline basis in TNNC1DiseaseGenCC HGNC:11943|MONDO:0012745Inferred only
familial isolated dilated cardiomyopathy has a germline basis in TNNC1DiseaseGenCC HGNC:11943|MONDO:0700335Inferred only
hypertrophic cardiomyopathy has a germline basis in TNNC1DiseaseGenCC HGNC:11943|MONDO:0005045Inferred only
hypertrophic cardiomyopathy 13 has a germline basis in TNNC1DiseaseGenCC HGNC:11943|MONDO:0013195Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: TNNC1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TNNC1 covaries with CALM1ProteinHetionet hetionet:covaries:7134-801Inferred only
TNNC1 covaries with GNAZProteinHetionet hetionet:covaries:2781-7134Inferred only
KCTD8 covaries with TNNC1ProteinHetionet hetionet:covaries:386617-7134Inferred only
TNNC1 covaries with KDELR3ProteinHetionet hetionet:covaries:11015-7134Inferred only
TNNC1 covaries with KRTAP10-9ProteinHetionet hetionet:covaries:386676-7134Inferred only
NPY5R covaries with TNNC1ProteinHetionet hetionet:covaries:4889-7134Inferred only
TNNC1 covaries with OR51E2ProteinHetionet hetionet:covaries:7134-81285Inferred only
RRAGA covaries with TNNC1ProteinHetionet hetionet:covaries:10670-7134Inferred only
CDK1 interacts with TNNC1ProteinHetionet hetionet:interacts:7134-983Inferred only
POLR2G interacts with TNNC1ProteinHetionet hetionet:interacts:5436-7134Inferred only
TNNC1 interacts with RBM15BProteinHetionet hetionet:interacts:29890-7134Inferred only
TNNC1 interacts with TCP10LProteinHetionet hetionet:interacts:140290-7134Inferred only

Show the remaining 16

TNNC1 interacts with TNNI1ProteinHetionet hetionet:interacts:7134-7135Inferred only
TNNC1 interacts with TNNI2ProteinHetionet hetionet:interacts:7134-7136Inferred only
TNNC1 interacts with TNNI3ProteinHetionet hetionet:interacts:7134-7137Inferred only
TNNC1 interacts with TNNT1ProteinHetionet hetionet:interacts:7134-7138Inferred only
TNNC1 interacts with TNNT2ProteinHetionet hetionet:interacts:7134-7139Inferred only
TNNC1 interacts with TRIM63ProteinHetionet hetionet:interacts:7134-84676Inferred only
TNNC1 interacts with UBCProteinHetionet hetionet:interacts:7134-7316Inferred only
TNNC1 interacts with UBE2CProteinHetionet hetionet:interacts:11065-7134Inferred only
TNNC1 participates in Caffeine in myocytesPathwayWikiPathways WP5603Inferred only
TNNC1 participates in MFAP5 mediated ovarian cancer cell motility and invasivenessPathwayWikiPathways WP3301Inferred only
TNNC1 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
TNNC1 participates in Striated Muscle ContractionPathwayReactome R-HSA-390522Inferred only
TNNC1 participates in Striated muscle contraction pathwayPathwayWikiPathways WP383Inferred only
TNNC1 regulates negative regulation of ATP-dependent activityBiological processgene ontology P63316|GO:0032780Inferred only
TNNC1 regulates regulation of muscle contractionBiological processgene ontology P63316|GO:0006937Inferred only
TNNC1 regulates regulation of muscle filament sliding speedBiological processgene ontology P63316|GO:0032972Inferred only

Other names

3 names

Resolves to: TNNC1

Also called: TN-CTNNCTroponin C, slow skeletal and cardiac muscles

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