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Proteins/UNIPROT:P01374

LTA

Protein·UNIPROT:P01374

Open in the graph

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo..

Function from UniProtKB (P01374), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

28 statements

28 statements · 4 reference databases · Subject: LTA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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LTA covaries with OR8B3ProteinHetionet hetionet:covaries:390271-4049Inferred only
LTA interacts with CLSPNProteinHetionet hetionet:interacts:4049-63967Inferred only
LGALS2 interacts with LTAProteinHetionet hetionet:interacts:3957-4049Inferred only
LTA interacts with LTBProteinHetionet hetionet:interacts:4049-4050Inferred only
LTA interacts with LTBRProteinHetionet hetionet:interacts:4049-4055Inferred only
LTA interacts with TNFProteinHetionet hetionet:interacts:4049-7124Inferred only
LTA interacts with TNFRSF14ProteinHetionet hetionet:interacts:4049-8764Inferred only
LTA interacts with TNFRSF1AProteinHetionet hetionet:interacts:4049-7132Inferred only
LTA interacts with TNFRSF1BProteinHetionet hetionet:interacts:4049-7133Inferred only
LTA interacts with TUBA1AProteinHetionet hetionet:interacts:4049-7846Inferred only
LTA interacts with TUBA4AProteinHetionet hetionet:interacts:4049-7277Inferred only
LTA interacts with UMODProteinHetionet hetionet:interacts:4049-7369Inferred only

Show the remaining 16

LTA participates in ApoptosisPathwayWikiPathways WP254Inferred only
LTA participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
LTA participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
LTA participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
LTA participates in Neuroinflammation and glutamatergic signalingPathwayWikiPathways WP5083Inferred only
LTA participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
LTA participates in T cell activation SARS CoV 2PathwayWikiPathways WP5098Inferred only
LTA participates in TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayPathwayReactome R-HSA-5676594Inferred only
LTA participates in TNFR2 non-canonical NF-kB pathwayPathwayReactome R-HSA-5668541Inferred only
LTA participates in TNFs bind their physiological receptorsPathwayReactome R-HSA-5669034Inferred only
LTA regulates negative regulation of fibroblast proliferationBiological processgene ontology P01374|GO:0048147Inferred only
LTA regulates positive regulation of canonical NF-kappaB signal transductionBiological processgene ontology P01374|GO:0043123Inferred only
LTA regulates positive regulation of extrinsic apoptotic signaling pathwayBiological processgene ontology P01374|GO:2001238Inferred only
LTA regulates positive regulation of glial cell proliferationBiological processgene ontology P01374|GO:0060252Inferred only
LTA regulates regulation of necroptotic processBiological processgene ontology P01374|GO:0060544Inferred only
LTA regulates regulation of type I interferon productionBiological processgene ontology P01374|GO:0032479Inferred only

Other names

5 names

Resolves to: LTA

Also called: LT-alphaTNF-betaTNFBTNFSF1Tumor necrosis factor ligand superfamily member 1

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