Proteins/UNIPROT:Q9NRS4

TMPRSS4

ProteinUNIPROT:Q9NRS4

Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC (By similarity)..

(Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry..

Function from UniProtKB (Q9NRS4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

autosomal recessive cerebral atrophy has a germline basis in TMPRSS4DiseaseGenCC HGNC:11878|MONDO:0018218Inferred only

Statements

18 statements

18 statements · 3 reference databases · Subject: TMPRSS4 · Sources: gene ontology, Hetionet, WikiPathways

Order

TMPRSS4 covaries with TMEM63BProteinHetionet hetionet:covaries:55362-56649Inferred only
TMPRSS4 participates in Epithelial to mesenchymal transition in colorectal cancerPathwayWikiPathways WP4239Inferred only
TMPRSS4 participates in SARS CoV 2 and COVID 19 pathwayPathwayWikiPathways WP4846Inferred only
TMPRSS4 regulates negative regulation of growth rateBiological processgene ontology Q9NRS4|GO:0045967Inferred only
TMPRSS4 regulates positive regulation of viral entry into host cellBiological processgene ontology Q9NRS4|GO:0046598Inferred only
TMPRSS4 regulates regulation of gene expressionBiological processgene ontology Q9NRS4|GO:0010468Inferred only
BID increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:637-56649Inferred only
C2CD2 increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:25966-56649Inferred only
CEBPD increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:1052-56649Inferred only
GALE decreases the expression of TMPRSS4ProteinHetionet hetionet:regulates:2582-56649Inferred only
IARS2 increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:55699-56649Inferred only
MAP2K5 increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:5607-56649Inferred only

Show the remaining 6

ME2 increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:4200-56649Inferred only
PJA2 increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:9867-56649Inferred only
PSAP increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:5660-56649Inferred only
SRM increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:6723-56649Inferred only
TSPAN4 increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:7106-56649Inferred only
YAP1 increases the expression of TMPRSS4ProteinHetionet hetionet:regulates:10413-56649Inferred only

Other names

6 names

Resolves to: TMPRSS4

Also called: [Cleaved into: Transmembrane protease serine 4 catalytic chain]CAPH2Channel-activating protease 2Membrane-type serine protease 2MT-SP2TMPRSS3

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