Pathway
Degradation of beta-catenin by the destruction complex
The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).
REACT:R-HSA-195253Reactome
What the reference databases state
Statements
70 statements
70 statements · 1 reference database · Subject: Degradation of beta-catenin by the destruction complex · Sources: Reactome
- ADRM1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- AMER1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- APC participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- AXIN1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- BTRC participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- CSNK1A1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- CTBP1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- CTBP2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- CTNNB1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- CUL1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- FRAT1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- FRAT2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
Show the remaining 58
- GSK3B participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- HDAC1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- LEF1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2CA participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2CB participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2R1A participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2R1B participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2R5A participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2R5B participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2R5C participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2R5D participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PPP2R5E participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMA1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMA2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMA3 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMA4 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMA5 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMA6 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMA7 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMB1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMB2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMB3 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMB4 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMB5 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMB6 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMB7 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMC1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMC2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMC3 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMC4 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMC5 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMC6 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD11 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD12 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD13 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD14 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD3 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD6 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD7 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- PSMD8 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- RBX1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- RPS27A participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- SEM1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- SKP1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TCF7 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TCF7L1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TCF7L2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TLE1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TLE2 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TLE3 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TLE4 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- TLE5 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- UBA52 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- UBB participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- UBC participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only
- ZRANB1 participates in Degradation of beta-catenin by the destruction complexProteinReactome R-HSA-195253Inferred only