Proteins/UNIPROT:Q6NUS6

TCTN3

ProteinUNIPROT:Q6NUS6

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway..

Function from UniProtKB (Q6NUS6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

ciliopathy has a germline basis in TCTN3DiseaseGenCC HGNC:24519|MONDO:0005308Inferred only
Joubert syndrome 18 has a germline basis in TCTN3DiseaseGenCC HGNC:24519|MONDO:0013896Inferred only
Meckel syndrome has a germline basis in TCTN3DiseaseGenCC HGNC:24519|MONDO:0018921Inferred only
orofaciodigital syndrome IV has a germline basis in TCTN3DiseaseGenCC HGNC:24519|MONDO:0009794Inferred only
orofaciodigital syndrome type 6 has a germline basis in TCTN3DiseaseGenCC HGNC:24519|MONDO:0010176Inferred only

Statements

36 statements

36 statements · 4 reference databases · Subject: TCTN3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CABS1 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-85438Inferred only
IFNE covaries with TCTN3ProteinHetionet hetionet:covaries:26123-338376Inferred only
IKZF4 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-64375Inferred only
OR10A3 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-26496Inferred only
OR1C1 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-26188Inferred only
OR1D5 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-8386Inferred only
OR2M4 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-26245Inferred only
PLEKHG4 covaries with TCTN3ProteinHetionet hetionet:covaries:25894-26123Inferred only
POLR2M covaries with TCTN3ProteinHetionet hetionet:covaries:26123-81488Inferred only
TCTN3 covaries with RHBDL2ProteinHetionet hetionet:covaries:26123-54933Inferred only
SERPINA7 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-6906Inferred only
SIX5 covaries with TCTN3ProteinHetionet hetionet:covaries:147912-26123Inferred only

Show the remaining 24

SPATA31H1 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-84226Inferred only
SPRED3 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-399473Inferred only
SUV39H1 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-6839Inferred only
VEGFA covaries with TCTN3ProteinHetionet hetionet:covaries:26123-7422Inferred only
ZFP14 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-57677Inferred only
TCTN3 covaries with ZFYVE9ProteinHetionet hetionet:covaries:26123-9372Inferred only
ZNF10 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-7556Inferred only
ZNF197 covaries with TCTN3ProteinHetionet hetionet:covaries:10168-26123Inferred only
ZNF26 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-7574Inferred only
ZNF432 covaries with TCTN3ProteinHetionet hetionet:covaries:26123-9668Inferred only
ZNF554 covaries with TCTN3ProteinHetionet hetionet:covaries:115196-26123Inferred only
TCTN3 participates in Anchoring of the basal body to the plasma membranePathwayReactome R-HSA-5620912Inferred only
TCTN3 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
TCTN3 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
TCTN3 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
TCTN3 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
TCTN3 participates in Joubert syndromePathwayWikiPathways WP4656Inferred only
TCTN3 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
TCTN3 regulates positive regulation of apoptotic processBiological processgene ontology Q6NUS6|GO:0043065Inferred only
ALPK1 increases the expression of TCTN3ProteinHetionet hetionet:regulates:80216-26123Inferred only
FOXO4 increases the expression of TCTN3ProteinHetionet hetionet:regulates:4303-26123Inferred only
HDAC6 increases the expression of TCTN3ProteinHetionet hetionet:regulates:10013-26123Inferred only
PRKCG increases the expression of TCTN3ProteinHetionet hetionet:regulates:5582-26123Inferred only
SRSF3 decreases the expression of TCTN3ProteinHetionet hetionet:regulates:6428-26123Inferred only

Other names

3 names

Resolves to: TCTN3

Also called: C10orf61TECT3Tectonic-3

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