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Proteins/UNIPROT:Q9UH77
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption. The BCR(KLHL3) complex also mediates ubiquitination and degradation of WNK3. The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (By similarity)..
Function from UniProtKB (Q9UH77), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
23 statements
23 statements · 2 reference databases · Subject: KLHL3 · Sources: Hetionet, Reactome
2 names
Resolves to: KLHL3