Proteins/UNIPROT:Q8IX90

SKA3

ProteinUNIPROT:Q8IX90

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules..

Function from UniProtKB (Q8IX90), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: SKA3 · Sources: gene ontology, Hetionet

Order

APP interacts with SKA3ProteinHetionet hetionet:interacts:221150-351Inferred only
AURKB interacts with SKA3ProteinHetionet hetionet:interacts:221150-9212Inferred only
PAXIP1 interacts with SKA3ProteinHetionet hetionet:interacts:221150-22976Inferred only
SPC24 interacts with SKA3ProteinHetionet hetionet:interacts:147841-221150Inferred only
SUMO2 interacts with SKA3ProteinHetionet hetionet:interacts:221150-6613Inferred only
UBC interacts with SKA3ProteinHetionet hetionet:interacts:221150-7316Inferred only
SKA3 regulates negative regulation of mitotic spindle assembly checkpoint signalingBiological processgene ontology Q8IX90|GO:0140499Inferred only
SKA3 regulates regulation of microtubule polymerization or depolymerizationBiological processgene ontology Q8IX90|GO:0031110Inferred only

Other names

3 names

Resolves to: SKA3

Also called: C13orf3RAMA1Spindle and kinetochore-associated protein 3

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