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Proteins/UNIPROT:P31639
Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity. Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity)..
Function from UniProtKB (P31639), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
14 statements
14 statements · 4 reference databases · Subject: SLC5A2 · Sources: Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
D-glucose+sodium(1+)D-glucose+sodium(1+)
Transported by SLC5A9 or SLC5A2 or SLC5A10 or SLC5A11
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05450CC BY 4.0Reference data
D-glucose+sodium(1+)D-glucose+sodium(1+)
Transported by SLC5A2
4 names
Resolves to: SLC5A2
Reaction pageLeft to rightBalanced
Rhea RHEA:70571CC BY 4.0Reference data