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Proteins/UNIPROT:Q8WWX8
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity)..
Function from UniProtKB (Q8WWX8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
22 statements
22 statements · 6 reference databases · Subject: SLC5A11 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
D-glucose+sodium(1+)D-glucose+sodium(1+)
Transported by SLC5A9 or SLC5A2 or SLC5A10 or SLC5A11
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05450CC BY 4.0Reference data
myo-inositol+2sodium(1+)myo-inositol+2sodium(1+)
Transported by
8 names
Resolves to: SLC5A11
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR08912CC BY 4.0Reference data
D-glucose+2sodium(1+)D-glucose+2sodium(1+)
Transported by SLC5A1 or SLC5A11
Reaction pageLeft to rightBalanced
Rhea RHEA:70495CC BY 4.0Reference data
myo-inositol+2sodium(1+)myo-inositol+2sodium(1+)
Transported by SLC5A3 or SLC5A11
Reaction pageDirection not assertedBalanced
Rhea RHEA:72987CC BY 4.0Reference data
CHEBI:27372+2sodium(1+)CHEBI:27372+2sodium(1+)
Transported by SLC5A11
Reaction pageDirection not assertedBalanced
Rhea RHEA:73315CC BY 4.0Reference data
D-xylose+2sodium(1+)D-xylose+2sodium(1+)
Transported by SLC5A11
Reaction pageDirection not assertedBalanced
Rhea RHEA:73367CC BY 4.0Reference data