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Proteins/UNIPROT:A0PJK1
[Isoform 1]: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney..
[Isoform 2]: Appears to have no transporter activity..
Function from UniProtKB (A0PJK1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
11 statements
11 statements · 4 reference databases · Subject: SLC5A10 · Sources: Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
D-glucose+sodium(1+)D-glucose+sodium(1+)
Transported by SLC5A9 or SLC5A2 or SLC5A10 or SLC5A11
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05450CC BY 4.0Reference data
D-mannose+sodium(1+)D-mannose+sodium(1+)
Transported by SLC5A10
4 names
Resolves to: SLC5A10
Reaction pageLeft to rightBalanced
Rhea RHEA:72907CC BY 4.0Reference data
D-fructopyranose+sodium(1+)D-fructopyranose+sodium(1+)
Transported by SLC5A10
Reaction pageLeft to rightBalanced
Rhea RHEA:72915CC BY 4.0Reference data