Proteins/UNIPROT:Q9BQF6

SENP7

ProteinUNIPROT:Q9BQF6

Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms..

Function from UniProtKB (Q9BQF6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

arthrogryposis multiplex congenita has a germline basis in SENP7DiseaseGenCC HGNC:30402|MONDO:0015168Inferred only

Statements

9 statements

9 statements · 1 reference database · Subject: SENP7 · Sources: Hetionet

Order

CENPE covaries with SENP7ProteinHetionet hetionet:covaries:1062-57337Inferred only
CHAMP1 covaries with SENP7ProteinHetionet hetionet:covaries:283489-57337Inferred only
SENP7 covaries with ETAA1ProteinHetionet hetionet:covaries:54465-57337Inferred only
KDM3B covaries with SENP7ProteinHetionet hetionet:covaries:51780-57337Inferred only
KLLN covaries with SENP7ProteinHetionet hetionet:covaries:100144748-57337Inferred only
NOL7 covaries with SENP7ProteinHetionet hetionet:covaries:51406-57337Inferred only
SENP7 covaries with ZNF432ProteinHetionet hetionet:covaries:57337-9668Inferred only
ZNF566 covaries with SENP7ProteinHetionet hetionet:covaries:57337-84924Inferred only
SENP7 covaries with ZNF570ProteinHetionet hetionet:covaries:148268-57337Inferred only

Other names

5 names

Resolves to: SENP7

Also called: KIAA1707Sentrin/SUMO-specific protease SENP7SSP2SUMO-1-specific protease 2SUSP2

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