arthrogryposis multiplex congenita
Findings
No curated finding names arthrogryposis multiplex congenita yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Arthrogryposis multiplex congenita (AMC) is a group of disorders characterized by congenital limb contractures. It manifests as limitation of movement of multiple limb joints at birth that is usually non-progressive and may include muscle weakness and fibrosis. AMC is always associated with decreased intrauterine fetal movement which leads secondarily to the contractures.
Definition from the Mondo Disease Ontology (MONDO:0015168), read 2026-09-29. CC BY 4.0.
Genes
4 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- Narrower terms (24)
- adducted thumbs-arthrogryposis syndrome, Christian type
- arthrogryposis due to muscular dystrophy
- arthrogryposis multiplex congenita 2, neurogenic type
- arthrogryposis multiplex congenita 3, myogenic type
- arthrogryposis multiplex congenita 4, neurogenic, with agenesis of the corpus callosum
- arthrogryposis multiplex congenita 5
- arthrogryposis multiplex congenita 6
- arthrogryposis multiplex congenita 7, X-linked
- arthrogryposis multiplex congenita-whistling face syndrome
- arthrogryposis-hyperkeratosis syndrome, lethal form
- arthrogryposis-like syndrome
- autosomal recessive myogenic arthrogryposis multiplex congenita
- fetal akinesia deformation sequence
- hypomyelination neuropathy-arthrogryposis syndrome
- infantile-onset X-linked spinal muscular atrophy
- lethal arthrogryposis-anterior horn cell disease syndrome
Other names
5 names
Resolves to: arthrogryposis multiplex congenita
- Also called
- AMCArthromyodysplasia congenitacongenital arthromyodysplasiamultiple congenital arthrogryposismyodysplasia