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Proteins/UNIPROT:P51172
Potential alternative pore-forming subunit of the epithelial sodium channel (ENaC), capable of replacing the alpha/SCNN1A subunit, creating a more active channel with distinct properties. ENaC functions in epithelial tissues, where it facilitates the electrodiffusion of sodium ions from the extracellular fluid through the apical membrane of cells, with water following osmotically, regulating sodium balance and fluid homeostasis. This subunit could also function independently as a sodium channel or assemble into other tissue-specific heterotrimeric sodium channels..
[Isoform 2]: ENaC channels including this isoform exhibit greater conductance..
Function from UniProtKB (P51172), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
14 statements
14 statements · 6 reference databases · Subject: SCNN1D · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
Transported by SCN1A or SCN2A or SCN3A or SCN4A or SCN5A or SCN7A or SCN8A or SCN9A or SCN10A or SCN11A or HCN1 or HCN4 and 5 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01527CC BY 4.0Reference data
8 names
Resolves to: SCNN1D
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data