Proteins/UNIPROT:Q8TAC9

SCAMP5

ProteinUNIPROT:Q8TAC9

Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway..

Function from UniProtKB (Q8TAC9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

complex neurodevelopmental disorder has a germline basis in SCAMP5DiseaseGenCC HGNC:30386|MONDO:0100038Inferred only
neurodevelopmental disorder has a germline basis in SCAMP5DiseaseGenCC HGNC:30386|MONDO:0700092Inferred only

Statements

13 statements

13 statements · 2 reference databases · Subject: SCAMP5 · Sources: gene ontology, Hetionet

Order

OBSL1 covaries with SCAMP5ProteinHetionet hetionet:covaries:192683-23363Inferred only
SCAMP5 covaries with PADI6ProteinHetionet hetionet:covaries:192683-353238Inferred only
PCDHB15 covaries with SCAMP5ProteinHetionet hetionet:covaries:192683-56121Inferred only
RNF215 covaries with SCAMP5ProteinHetionet hetionet:covaries:192683-200312Inferred only
SCAMP5 covaries with TRIM68ProteinHetionet hetionet:covaries:192683-55128Inferred only
SCAMP5 covaries with ZNF26ProteinHetionet hetionet:covaries:192683-7574Inferred only
ZNF879 covaries with SCAMP5ProteinHetionet hetionet:covaries:192683-345462Inferred only
PAXIP1 interacts with SCAMP5ProteinHetionet hetionet:interacts:192683-22976Inferred only
PLAU interacts with SCAMP5ProteinHetionet hetionet:interacts:192683-5328Inferred only
SLC9A7 interacts with SCAMP5ProteinHetionet hetionet:interacts:192683-84679Inferred only
SCAMP5 regulates negative regulation of endocytosisBiological processgene ontology Q8TAC9|GO:0045806Inferred only
SCAMP5 regulates positive regulation of calcium ion-dependent exocytosisBiological processgene ontology Q8TAC9|GO:0045956Inferred only

Show the remaining 1

SCAMP5 regulates positive regulation of cytokine productionBiological processgene ontology Q8TAC9|GO:0001819Inferred only

Other names

2 names

Resolves to: SCAMP5

Also called: hSCAMP5Secretory carrier membrane protein 5

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