PADI6

Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development. Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos: they are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development. Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive. PADI6 oligomers acts as an essential structural scaffolding element of cytoplasmic lattices (By similarity). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+)..

Function from UniProtKB (Q6TGC4), read 2026-09-23. CC BY 4.0.