Proteins/UNIPROT:Q8IXW5

RPAP2

ProteinUNIPROT:Q8IXW5

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis..

Function from UniProtKB (Q8IXW5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 2 reference databases · Subject: RPAP2 · Sources: Hetionet, Reactome

Order

IL10RA covaries with RPAP2ProteinHetionet hetionet:covaries:3587-79871Inferred only
ZNF554 covaries with RPAP2ProteinHetionet hetionet:covaries:115196-79871Inferred only
ZNF566 covaries with RPAP2ProteinHetionet hetionet:covaries:79871-84924Inferred only
ZNF570 covaries with RPAP2ProteinHetionet hetionet:covaries:148268-79871Inferred only
RPAP2 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
RPAP2 participates in RNA polymerase II transcribes snRNA genesPathwayReactome R-HSA-6807505Inferred only
RPAP2 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only

Reactions

2 reactions

O-phospho-L-seryl-[protein]+waterL-seryl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 61 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

2 names

Resolves to: RPAP2

Also called: C1orf82RNA polymerase II-associated protein 2

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