Pathway
Downstream signal transduction
The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.
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Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.
What the reference databases state
Statements
26 statements
26 statements · 1 reference database · Subject: Downstream signal transduction · Sources: Reactome
- BCAR1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- CRK participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- CRKL participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- GRB7 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- HRAS participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- NCK1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- NCK2 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- NRAS participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PDGFB participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PDGFRA participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PDGFRB participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PIK3CA participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
Show the remaining 14
- PIK3CB participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PIK3R1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PIK3R2 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PLCG1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- PTPN11 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- RAPGEF1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- RASA1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- SOS1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- SRC participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- STAT1 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- STAT3 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- STAT5A participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- STAT5B participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only
- STAT6 participates in Downstream signal transductionProteinReactome R-HSA-186763Inferred only