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Proteins/UNIPROT:O75051
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)..
Function from UniProtKB (O75051), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
37 statements
37 statements · 4 reference databases · Subject: PLXNA2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 names
Resolves to: PLXNA2