Proteins/UNIPROT:P01213

PDYN

ProteinUNIPROT:P01213

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)..

Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity)..

Leumorphin has a typical opioid activity and may have anti-apoptotic effect..

Function from UniProtKB (P01213), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

spinocerebellar ataxia type 23 has a germline basis in PDYNDiseaseGenCC HGNC:8820|MONDO:0012449Inferred only

Statements

29 statements

29 statements · 3 reference databases · Subject: PDYN · Sources: Hetionet, Reactome, WikiPathways

Order

PDYN covaries with ACTL8ProteinHetionet hetionet:covaries:5173-81569Inferred only
PDYN covaries with AMZ2ProteinHetionet hetionet:covaries:51321-5173Inferred only
PDYN covaries with ANO5ProteinHetionet hetionet:covaries:203859-5173Inferred only
PDYN covaries with BABAM1ProteinHetionet hetionet:covaries:29086-5173Inferred only
PDYN covaries with C19orf18ProteinHetionet hetionet:covaries:147685-5173Inferred only
PDYN covaries with C1orf52ProteinHetionet hetionet:covaries:148423-5173Inferred only
PDYN covaries with CFAP210ProteinHetionet hetionet:covaries:129881-5173Inferred only
PDYN covaries with CLEC16AProteinHetionet hetionet:covaries:23274-5173Inferred only
PDYN covaries with HSPA5ProteinHetionet hetionet:covaries:3309-5173Inferred only
PDYN covaries with IL34ProteinHetionet hetionet:covaries:146433-5173Inferred only
PDYN covaries with KLHL13ProteinHetionet hetionet:covaries:5173-90293Inferred only
PDYN covaries with KLHL26ProteinHetionet hetionet:covaries:5173-55295Inferred only

Show the remaining 17

PDYN covaries with MDN1ProteinHetionet hetionet:covaries:23195-5173Inferred only
PDYN covaries with MVB12AProteinHetionet hetionet:covaries:5173-93343Inferred only
PDYN covaries with SLCO6A1ProteinHetionet hetionet:covaries:133482-5173Inferred only
PDYN covaries with TEX10ProteinHetionet hetionet:covaries:5173-54881Inferred only
PDYN covaries with TRPC3ProteinHetionet hetionet:covaries:5173-7222Inferred only
APP interacts with PDYNProteinHetionet hetionet:interacts:351-5173Inferred only
NRDC interacts with PDYNProteinHetionet hetionet:interacts:4898-5173Inferred only
PDYN participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
PDYN participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
PDYN participates in G-protein activationPathwayReactome R-HSA-202040Inferred only
PDYN participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
PDYN participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
PDYN participates in Opioid SignallingPathwayReactome R-HSA-111885Inferred only
PDYN participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
PDYN participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PDYN participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
PDYN participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only

Other names

13 names

Resolves to: PDYN

Also called: ; Leumorphin1-131-171-8Beta-neoendorphin-dynorphinBig DynDyn-A17Dyn-BDynorphin ADynorphin BDynorphin B-29Dynorphin B(1-13)Preprodynorphin

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