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Proteins/UNIPROT:Q9UHG3
Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded..
Function from UniProtKB (Q9UHG3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
41 statements
41 statements · 5 reference databases · Subject: PCYOX1 · Sources: Bgee, Hetionet, Human-GEM, Rhea, UniProt
4 reactions
S-(2E,6E)-farnesyl-L-cysteine+water+dioxygen(2E,6E)-farnesal+L-cysteine+hydrogen peroxide
Catalysed by PCYOX1
Reaction pageLeft to rightBalancedEC 1.8.3.5, 1.8.3.6cytosol
Human-GEM MAR07170CC BY 4.0Reference data
S-(2E,6E)-farnesyl-L-cysteine+dioxygen+water(2E,6E)-farnesal+L-cysteine
3 names
Resolves to: PCYOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:30231CC BY 4.0Reference data
an S-polyprenyl-L-cysteine+dioxygen+watera polyprenal+L-cysteine+hydrogen peroxide
Catalysed by PCYOX1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53892CC BY 4.0Reference data
[(2E,6E,10E)-geranylgeranyl]-L-cysteine+dioxygen+water(2E,6E,10E)-geranylgeranial+L-cysteine+hydrogen peroxide
Catalysed by PCYOX1L or PCYOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:70407CC BY 4.0Reference data