Proteins/UNIPROT:Q96S42

NODAL

ProteinUNIPROT:Q96S42

Open in the graph

Essential for mesoderm formation and axial patterning during embryonic development..

Function from UniProtKB (Q96S42), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

congenital heart disease with heterotaxy syndrome has a germline basis in NODALDiseaseGenCC HGNC:7865|MONDO:1060197Inferred only
heterotaxy, visceral, 5, autosomal has a germline basis in NODALDiseaseGenCC HGNC:7865|MONDO:0700112Inferred only

Statements

37 statements

37 statements · 4 reference databases · Subject: NODAL · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CEP68 covaries with NODALProteinHetionet hetionet:covaries:23177-4838Inferred only
FRAT2 covaries with NODALProteinHetionet hetionet:covaries:23401-4838Inferred only
GDF3 covaries with NODALProteinHetionet hetionet:covaries:4838-9573Inferred only
H2AC11; H2AC13; H2AC15; H2AC16; H2AC17 covaries with NODALProteinHetionet hetionet:covaries:4838-8330Inferred only
H2BC15 covaries with NODALProteinHetionet hetionet:covaries:4838-8341Inferred only
PCSK1N covaries with NODALProteinHetionet hetionet:covaries:27344-4838Inferred only
NODAL covaries with PERM1ProteinHetionet hetionet:covaries:4838-84808Inferred only
PPP1R3F covaries with NODALProteinHetionet hetionet:covaries:4838-89801Inferred only
SCARF2 covaries with NODALProteinHetionet hetionet:covaries:4838-91179Inferred only
SLC2A11 covaries with NODALProteinHetionet hetionet:covaries:4838-66035Inferred only
SP7 covaries with NODALProteinHetionet hetionet:covaries:121340-4838Inferred only
TRIM68 covaries with NODALProteinHetionet hetionet:covaries:4838-55128Inferred only

Show the remaining 25

UFSP1 covaries with NODALProteinHetionet hetionet:covaries:402682-4838Inferred only
NODAL covaries with VWA1ProteinHetionet hetionet:covaries:4838-64856Inferred only
XKRX covaries with NODALProteinHetionet hetionet:covaries:402415-4838Inferred only
ZNF655 covaries with NODALProteinHetionet hetionet:covaries:4838-79027Inferred only
NODAL participates in Cardiac progenitor differentiationPathwayWikiPathways WP2406Inferred only
NODAL participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
NODAL participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
NODAL participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
NODAL participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
NODAL participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
NODAL participates in Pluripotent stem cell differentiation pathwayPathwayWikiPathways WP2848Inferred only
NODAL participates in Regulation of signaling by NODALPathwayReactome R-HSA-1433617Inferred only
NODAL participates in Signaling by NODALPathwayReactome R-HSA-1181150Inferred only
NODAL participates in Tgif disruption of Shh signalingPathwayWikiPathways WP3674Inferred only
NODAL regulates negative regulation of androgen receptor signaling pathwayBiological processgene ontology Q96S42|GO:0060766Inferred only
NODAL regulates negative regulation of chorionic trophoblast cell proliferationBiological processgene ontology Q96S42|GO:1901383Inferred only
NODAL regulates negative regulation of trophoblast cell migrationBiological processgene ontology Q96S42|GO:1901164Inferred only
NODAL regulates positive regulation of angiogenesisBiological processgene ontology Q96S42|GO:0045766Inferred only
NODAL regulates positive regulation of cell-cell adhesionBiological processgene ontology Q96S42|GO:0022409Inferred only
NODAL regulates positive regulation of epithelial cell proliferationBiological processgene ontology Q96S42|GO:0050679Inferred only
NODAL regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q96S42|GO:0070374Inferred only
NODAL regulates positive regulation of SMAD protein signal transductionBiological processgene ontology Q96S42|GO:0060391Inferred only
NODAL regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q96S42|GO:0045944Inferred only
NODAL regulates positive regulation of vascular endothelial growth factor productionBiological processgene ontology Q96S42|GO:0010575Inferred only
NODAL regulates regulation of stem cell population maintenanceBiological processgene ontology Q96S42|GO:2000036Inferred only

Other names

1 name

Resolves to: NODAL

Also called: Nodal homolog

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